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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2011-1-5
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pubmed:abstractText |
Nontoxic multinodular goiter (MNG) is frequently observed in the general population, but little is known about the underlying genetic susceptibility to this disease. Familial cases of MNG have been reported, and published reports describe 5 families that also contain at least 1 individual with a Sertoli-Leydig cell tumor of the ovary (SLCT). Germline mutations in DICER1, a gene that codes for an RNase III endoribonuclease, have been identified in families affected by pleuropulmonary blastoma (PPB), some of whom include cases of MNG and gonadal tumors such as SLCTs.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1538-3598
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pubmed:author |
pubmed-author:ArseneauJocelyneJ,
pubmed-author:BahubeshiAminA,
pubmed-author:BonoraElenaE,
pubmed-author:Bouron-Dal SoglioDorothéeD,
pubmed-author:BroderickPeterP,
pubmed-author:FoulkesWilliam DWD,
pubmed-author:GilbertLucyL,
pubmed-author:HamelNancyN,
pubmed-author:HarachH RubénHR,
pubmed-author:HoulstonRichard SRS,
pubmed-author:KanellopoulouChryssaC,
pubmed-author:LesueurFabienneF,
pubmed-author:LivingstonDavid MDM,
pubmed-author:MuljoStefanS,
pubmed-author:NguyenVan-HungVH,
pubmed-author:NiedzielaMarekM,
pubmed-author:O'BrienPaul KPK,
pubmed-author:PouchetCarlyC,
pubmed-author:PriestJohn RJR,
pubmed-author:Rio FrioThomasT,
pubmed-author:SabbaghianNellyN,
pubmed-author:SchimkeR NeilRN,
pubmed-author:SchultzKris AnnKA,
pubmed-author:SerdozL LLL,
pubmed-author:TischkowitzMarcM
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pubmed:issnType |
Electronic
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pubmed:day |
5
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pubmed:volume |
305
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
68-77
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pubmed:meshHeading |
pubmed-meshheading:21205968-Adolescent,
pubmed-meshheading:21205968-Adult,
pubmed-meshheading:21205968-Child,
pubmed-meshheading:21205968-DEAD-box RNA Helicases,
pubmed-meshheading:21205968-DNA Mutational Analysis,
pubmed-meshheading:21205968-Female,
pubmed-meshheading:21205968-Genetic Predisposition to Disease,
pubmed-meshheading:21205968-Germ-Line Mutation,
pubmed-meshheading:21205968-Goiter, Nodular,
pubmed-meshheading:21205968-Humans,
pubmed-meshheading:21205968-Male,
pubmed-meshheading:21205968-MicroRNAs,
pubmed-meshheading:21205968-Mutation, Missense,
pubmed-meshheading:21205968-Ovarian Neoplasms,
pubmed-meshheading:21205968-Pulmonary Blastoma,
pubmed-meshheading:21205968-Ribonuclease III,
pubmed-meshheading:21205968-Sertoli-Leydig Cell Tumor,
pubmed-meshheading:21205968-Young Adult
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pubmed:year |
2011
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pubmed:articleTitle |
DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors.
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pubmed:affiliation |
Program in Cancer Genetics, Department of Oncology, McGill University Health Centre, Montreal, Quebec, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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