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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1990-11-6
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pubmed:abstractText |
High-dose thiotepa with autologous bone marrow rescue is a new and promising treatment modality in several kinds of solid tumors. We used this regimen in a pediatric patient who had the third recurrence of his malignant oligodendroglioma of brain that developed during '8 in 1' chemotherapy. We achieved complete response after a total dose of 1125 mg/m2 of intravenous thiotepa. Good penetration into the CNS renders thiotepa potentially useful for chemosensitive brain tumors, and one course of high-dose thiotepa can be administered with acceptable toxicity by utilizing autologous bone marrow rescue.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0167-594X
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
57-61
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:2120394-Bone Marrow Transplantation,
pubmed-meshheading:2120394-Brain Neoplasms,
pubmed-meshheading:2120394-Child,
pubmed-meshheading:2120394-Combined Modality Therapy,
pubmed-meshheading:2120394-Dose-Response Relationship, Drug,
pubmed-meshheading:2120394-Humans,
pubmed-meshheading:2120394-Male,
pubmed-meshheading:2120394-Neoplasm Recurrence, Local,
pubmed-meshheading:2120394-Oligodendroglioma,
pubmed-meshheading:2120394-Pilot Projects,
pubmed-meshheading:2120394-Thiotepa,
pubmed-meshheading:2120394-Transplantation, Autologous
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pubmed:year |
1990
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pubmed:articleTitle |
High-dose thiotepa with autologous bone marrow rescue in recurrent malignant oligodendroglioma: a case report.
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pubmed:affiliation |
Children's Hospital, University of Helsinki, Finland.
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pubmed:publicationType |
Journal Article,
Case Reports
|