| pubmed-article:2120354 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2120354 | lifeskim:mentions | umls-concept:C0011616 | lld:lifeskim |
| pubmed-article:2120354 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:2120354 | lifeskim:mentions | umls-concept:C0023005 | lld:lifeskim |
| pubmed-article:2120354 | lifeskim:mentions | umls-concept:C0221920 | lld:lifeskim |
| pubmed-article:2120354 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:2120354 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:2120354 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:2120354 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2120354 | pubmed:dateCreated | 1990-11-6 | lld:pubmed |
| pubmed-article:2120354 | pubmed:abstractText | To investigate whether Langerhans cells are capable of inducing contact sensitivity effector T cells, we incubated purified T cells from naive mice with syngeneic cultured trinitrophenyl-modified Langerhans cells for 4-5 d. The cells were then expanded in interleukin-2 and fresh medium for another 6-9 d and injected intravenously into naive syngeneic recipient mice. After the ears of recipient mice were painted with 1% trinitrochlorobenzene, we observed an ear-swelling response peaking at 24-48 h. The ear-swelling response was hapten specific. CD8- but not CD4-depleted T cells mediated strong contact sensitivity. Systemic adoptive transfer into nude mice also lead to a hapten-specific delayed ear-swelling response. However, this response was less protracted than in euthymic animals, suggesting the participation of the recipient (non-immunized) T cells in the ear-swelling response of the euthymic mice. Lymphokine analysis of in vitro primed and restimulated T cells revealed predominant production of interleukin-2 but little or no interleukin-4. These in vitro primed cells therefore resemble type 1 or inflammatory T helper cell clones. | lld:pubmed |
| pubmed-article:2120354 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2120354 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2120354 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2120354 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2120354 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2120354 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2120354 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2120354 | pubmed:issn | 0022-202X | lld:pubmed |
| pubmed-article:2120354 | pubmed:author | pubmed-author:HausenGG | lld:pubmed |
| pubmed-article:2120354 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2120354 | pubmed:volume | 95 | lld:pubmed |
| pubmed-article:2120354 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2120354 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2120354 | pubmed:pagination | 436-40 | lld:pubmed |
| pubmed-article:2120354 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:2120354 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2120354 | pubmed:articleTitle | Cultured epidermal Langerhans cells activate effector T cells for contact sensitivity. | lld:pubmed |
| pubmed-article:2120354 | pubmed:affiliation | Department of Dermatology, Hôpital Cantonal Universitaire, Geneva, Switzerland. | lld:pubmed |
| pubmed-article:2120354 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2120354 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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