Linked Life Data

2120331

Source:http://linkedlifedata.com/resource/pubmed/id/2120331

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1990-11-8
pubmed:databankReference
pubmed:abstractText
We studied a case of nonsecretory alpha-chain disease. The proliferating plasma cells contained a short transcript coding for a truncated membrane-form alpha 1-chain. The productive alpha-gene bore several noncontiguous deletions affecting the VHDJH and CH1 regions. Two deletions were accompanied with peculiar insertions containing duplications. The first insertion contained an acceptor splice site and was present in part in the mature transcript, thus coding for an abnormal aminoterminal peptide. Another deletion located 3' to CH3 eliminated the polyadenylation site of secreted-form alpha-mRNA. As a result, only membrane-form alpha mRNA was present in the tumoral plasma cells, thus explaining the nonsecretory phenotype of the disease. Comparison of cDNA and genomic sequences showed that the previously undescribed human alpha membrane region is encoded by a single exon, beginning with two alternate acceptor splice sites, and comprises either 65 or 71 amino acids.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
145
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2455-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Gene deletions force nonsecretory alpha-chain disease plasma cells to produce membrane-form alpha-chain only.
pubmed:affiliation
CNRS URA 1172, Faculté des Sciences, Poitiers, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't