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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-3-29
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pubmed:abstractText |
The mechanism by which hepcidin regulates iron export from macrophages has been well established and is believed to involve degradation of ferroportin. However, in the small intestine, hepcidin's mechanisms of action are not known. We studied human polarized intestinal (Caco-2/TC7) cells and mouse duodenal segments, ex vivo, to investigate the molecular mechanisms by which hepcidin down-regulates intestinal transepithelial iron transport.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1528-0012
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
140
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1261-1271.e1
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pubmed:meshHeading |
pubmed-meshheading:21199652-Animals,
pubmed-meshheading:21199652-Antimicrobial Cationic Peptides,
pubmed-meshheading:21199652-Caco-2 Cells,
pubmed-meshheading:21199652-Cation Transport Proteins,
pubmed-meshheading:21199652-Down-Regulation,
pubmed-meshheading:21199652-Duodenum,
pubmed-meshheading:21199652-Gene Expression,
pubmed-meshheading:21199652-Green Fluorescent Proteins,
pubmed-meshheading:21199652-Homeostasis,
pubmed-meshheading:21199652-Humans,
pubmed-meshheading:21199652-Intestinal Mucosa,
pubmed-meshheading:21199652-Iron,
pubmed-meshheading:21199652-Iron Radioisotopes,
pubmed-meshheading:21199652-Male,
pubmed-meshheading:21199652-Mice,
pubmed-meshheading:21199652-Mice, Inbred C57BL,
pubmed-meshheading:21199652-Proteasome Endopeptidase Complex,
pubmed-meshheading:21199652-Transcription Factors,
pubmed-meshheading:21199652-Ubiquitination
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pubmed:year |
2011
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pubmed:articleTitle |
Intestinal DMT1 cotransporter is down-regulated by hepcidin via proteasome internalization and degradation.
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pubmed:affiliation |
INSERM U773, Centre de Recherche Biomédicale Bichat Beaujon CRB3, Université Paris Diderot, site Bichat, Paris, France. carole.lagnel@univ-rouen.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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