Linked Life Data

2119913

Source:http://linkedlifedata.com/resource/pubmed/id/2119913

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-11-15
pubmed:abstractText
8 rabbits were infected percutaneously with the cercariae of Schistosoma japonicum. After hepatic fibrosis had developed in these rabbits 4 months after infection, 4 out of the 8 infected rabbits were given colchicine orally at a dosage of 40 micrograms/kg per day for 7 weeks. Another uninfected rabbits were used as controls. The therapeutic effects of colchicine on hepatic fibrosis were studied by transmission electron microscopy and morphometry, in which the area of collagen microfibrils in the space of disse and liver cells was measured. The results showed that colchicine relieved ultrastructural injury of liver cells and reduced the number of active fibroblasts and collagen microfibrils. The area of collagen microfibrils measured in the liver of the infected rabbits and colchicine-treated rabbits accounted for 42.5% and 0.2%, respectively (P less than 0.01), suggesting that colchicine has therapeutic effect against schistosomal liver fibrosis.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1000-7423
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
84-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
[Ultrastructural studies on effects of colchicine in treating hepatic fibrosis of schistosomiasis rabbits].
pubmed:affiliation
Department of Biophysics, Faculty of Basic Medical Science, Hua Shan Hospital, Shanghai Medical University.
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't