Linked Life Data

21198747

Source:http://linkedlifedata.com/resource/pubmed/id/21198747

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-1-4
pubmed:abstractText
In recent years, a large number of studies have contributed to our understanding of the immunosuppressive mechanisms used by mesenchymal stromal cells (MSC). These include the expression of indoleamine 2,3-dioxygenase (IDO) and the production of soluble immunosuppressive factors, such as, interleukin-10 (IL-10), transforming growth factor ? (TGF-?) and prostaglandin E2 (PGE2). However, whether these factors represent the only triggers involved in immunosuppression is not clear. Indeed, adding IDO inhibitor or neutralizing antibodies against IL-10 and TGF-? to mixed lymphocyte reactions failed to prevent T-cell suppression by MSC, suggesting that there is either redundancy in the mechanisms of immunosuppression or the involvement of other factors yet to be described. Galectins, a family of ?-galactoside binding proteins, now emerge as a main regulator of MSC immunosuppressive function. Galectin-1 and galectin-3 are constitutively expressed and secreted by human bone marrow MSC. Inhibition of galectin-1 and galectin-3 gene expression with small interfering RNAs abrogated the suppressive effect of MSC on allogeneic T cells. An increase in our understanding of MSC suppressor mechanisms will offer an insight into the use of these cells in human therapy such as the treatment of graft-versus-host disease, a severe complication after haematopoietic stem cell transplantation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1365-3083
pubmed:author
pubmed:copyrightInfo
© 2011 The Author. Scandinavian Journal of Immunology © 2011 Blackwell Publishing Ltd.
pubmed:issnType
Electronic
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
79-84
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
New insights into mesenchymal stromal cell-mediated T-cell suppression through galectins.
pubmed:affiliation
Department of Immunology, Institute for Cancer Research, Radiumhospitalet-Rikshospitalet University Hospital, Montebello, Oslo, Norway. mouldy.sioud@rr-research.no
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't