Linked Life Data

21196372

Source:http://linkedlifedata.com/resource/pubmed/id/21196372

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2011-1-3
pubmed:abstractText
Retraction artifacts are well known phenomenon in diagnostic surgical pathology for a long time but they were usually considered as artificially produced tissue alteration. Some recent studies of retraction artifact in different tumors have focused on its diagnostic and/or prognostic role. Their presence in prostatic carcinoma may be used in diagnostic and prognostic purposes. Peritumoral retraction artefacts in prostatic carcinoma are more pronounced and more common around neoplastic glands compared to benign glands, gland with prostatic intraepithelial neoplasia and postatrophic hyperplasia that is the one of the most common mimickers of prostatic carcinoma. In addition, the presence of extensive retraction artifact in prostatic carcinomas is clearly associated with tumor features that indicate a more aggressive tumor phenotype and with shorter biochemical recurrence-free survival. Studies at the molecular level demonstrate that retraction artifact may be attributed to molecules produced by reactive cancer stroma. The origin of retraction artifact in tumor specimens is unknown but they are probably the consequence of lack of basal cells and /or stromal changes but not simply artifacts due to laboratory procedures.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1945-0524
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
226-35
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Periacinar retraction artifact of the prostate.
pubmed:affiliation
Ljudevit Jurak Department of Pathology, Sestre milosrdnice University Hospital, Vinogradska 28, 10 000 Zagreb, Croatia. bkruslin@kbsm.hr
pubmed:publicationType
Journal Article, Review