Linked Life Data

21196316

Source:http://linkedlifedata.com/resource/pubmed/id/21196316

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2011-1-3
pubmed:abstractText
An undesirable effect associated with bisphosphonates is osteonecrosis of the jaw (ONJ). Case reports discussed ONJ development in patients with multiple myeloma or metastatic cancers receiving bisphosphonates as palliation for malignant bone disease. No causative relationship has been unequivocally demonstrated between ONJ and bisphosphonate therapy. To determine if a higher sensitivity to bisphosphonates could in part explain the development of ONJ, the segregation of A/C rs2297480 polymorphism of gene encoding for the farnesyl pyrophosphate synthase (FDPS) with ONJ was evaluated in a cohort of 68 Caucasian patients treated with zoledronic acid for multiple myeloma and metastatic mammary and prostate cancer. The AA and CC genotypes were highly differently distributed among ONJ patients and controls, matched for sex and type of malignant disease, with a positive correlation between AA carrier status and occurrence of ONJ (p=0.03) after 18-24 months of treatment. Because FDPS gene variants have been associated with bone morbidity, these pharmacogenetic association likely reflect the interaction of amino-bisphosphonates with germline sensitivity to drug actions, and might identify patients at highest risk to develop ONJ.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1945-0508
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
364-70
pubmed:meshHeading
pubmed-meshheading:21196316-Bone Density Conservation Agents, pubmed-meshheading:21196316-Diphosphonates, pubmed-meshheading:21196316-European Continental Ancestry Group, pubmed-meshheading:21196316-Female, pubmed-meshheading:21196316-Gene Frequency, pubmed-meshheading:21196316-Genetic Predisposition to Disease, pubmed-meshheading:21196316-Geranyltranstransferase, pubmed-meshheading:21196316-Humans, pubmed-meshheading:21196316-Imidazoles, pubmed-meshheading:21196316-Italy, pubmed-meshheading:21196316-Jaw Diseases, pubmed-meshheading:21196316-Male, pubmed-meshheading:21196316-Multiple Myeloma, pubmed-meshheading:21196316-Osteonecrosis, pubmed-meshheading:21196316-Pharmacogenetics, pubmed-meshheading:21196316-Polymorphism, Single Nucleotide, pubmed-meshheading:21196316-Retrospective Studies
pubmed:year
2011
pubmed:articleTitle
Pharmacogenetics of bisphosphonate-associated osteonecrosis of the jaw.
pubmed:affiliation
Department of Internal Medicine, University of Florence, Medical School, Florence, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't