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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2011-1-3
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pubmed:abstractText |
A key regulator of proliferation, differentiation and cell fate, the c-Myb transcription factor regulates the expression of hundreds of genes and is in turn regulated by numerous pathways and protein interactions. However, the most unique feature of c-Myb is that it can be converted into an oncogenic transforming protein through a few mutations that completely change its activity and specificity. The c-Myb protein is a myriad of interactions and activities rolled up in a protein that controls proliferation and differentiation in many different cell types. Here we discuss the background and recent progress that have led to a better understanding of this complex protein, and outline the questions that have yet to be answered.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MYBL1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MYBL2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MicroRNAs,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins v-myb,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-myb,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins
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pubmed:status |
MEDLINE
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pubmed:issn |
1093-4715
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1109-31
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pubmed:meshHeading |
pubmed-meshheading:21196221-Alternative Splicing,
pubmed-meshheading:21196221-Animals,
pubmed-meshheading:21196221-Cell Cycle Proteins,
pubmed-meshheading:21196221-Cell Differentiation,
pubmed-meshheading:21196221-Cell Proliferation,
pubmed-meshheading:21196221-Cell Transformation, Viral,
pubmed-meshheading:21196221-DNA-Binding Proteins,
pubmed-meshheading:21196221-Humans,
pubmed-meshheading:21196221-Leukemia,
pubmed-meshheading:21196221-MicroRNAs,
pubmed-meshheading:21196221-Neoplasms,
pubmed-meshheading:21196221-Oncogene Proteins v-myb,
pubmed-meshheading:21196221-Proto-Oncogene Proteins,
pubmed-meshheading:21196221-Proto-Oncogene Proteins c-myb,
pubmed-meshheading:21196221-Signal Transduction,
pubmed-meshheading:21196221-Stem Cells,
pubmed-meshheading:21196221-Trans-Activators,
pubmed-meshheading:21196221-Wnt Proteins
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pubmed:year |
2011
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pubmed:articleTitle |
Myb proteins: angels and demons in normal and transformed cells.
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pubmed:affiliation |
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131-0001, USA.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, N.I.H., Extramural
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