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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-1-11
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pubmed:abstractText |
N-type calcium channels (Ca(v)2.2) have been shown to play a critical role in pain. A series of low molecular weight 2-aryl indoles were identified as potent Ca(v)2.2 blockers with good in vitro and in vivo potency.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:AbbadieCatherineC,
pubmed-author:BugianesiRandall MRM,
pubmed-author:ChakravartyPrasun KPK,
pubmed-author:DuffyJoseph LJL,
pubmed-author:ForrestMichael JMJ,
pubmed-author:GarciaMariaM,
pubmed-author:GreenMitchellM,
pubmed-author:HaedoRodolfo JRJ,
pubmed-author:HerringtonJames BJB,
pubmed-author:JochnowitzNinaN,
pubmed-author:KaczorowskiGregory JGJ,
pubmed-author:KaranamBindhuB,
pubmed-author:LiXiaohuaX,
pubmed-author:LyonsKathryn AKA,
pubmed-author:MadeiraMariaM,
pubmed-author:McGowanErinE,
pubmed-author:McManusOwen BOB,
pubmed-author:MistryShrutiS,
pubmed-author:ParkMinM,
pubmed-author:RatliffKevinK,
pubmed-author:SmithMcHardyM,
pubmed-author:SwensenAndrew MAM,
pubmed-author:TyagarajanSriramS,
pubmed-author:WarrenVivien AVA,
pubmed-author:WilliamsBrandeB,
pubmed-author:ZhouBishanB
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
869-73
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pubmed:meshHeading |
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pubmed:year |
2011
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pubmed:articleTitle |
A potent and selective indole N-type calcium channel (Ca(v)2.2) blocker for the treatment of pain.
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pubmed:affiliation |
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. sriram_tyagarajan@merck.com
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pubmed:publicationType |
Journal Article
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