Linked Life Data

21195098

Source:http://linkedlifedata.com/resource/pubmed/id/21195098

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2011-3-4
pubmed:abstractText
The knowledge that excitatory synapses on aspiny hippocampal interneurons can develop genuine forms of activity-dependent remodeling, independently from the surrounding network of principal cells, is a relatively new concept. Cumulative evidence has now unequivocally demonstrated that, despite the absence of specialized postsynaptic spines that serve as compartmentalized structure for intracellular signaling in principal cell plasticity, excitatory inputs onto interneurons can undergo forms of synaptic plasticity that are induced and expressed autonomously from principal cells. Yet, the rules for induction and expression of interneuron plasticity are much more heterogeneous than in principal neurons. Long-term plasticity in interneurons is not necessarily dependent upon postsynaptic activation of NMDA receptors nor relies on the same postsynaptic membrane potential requirements as principal cells. Plasticity in interneurons rather requires activation of Ca(2+)-permeable AMPA receptors and/or metabotropic glutamate receptors and is triggered by postsynaptic hyperpolarization. In this review we will outline these distinct features of interneuron plasticity and identify potential critical candidate molecules that might be important for sustaining long-lasting changes in synaptic strength at excitatory inputs onto interneurons. This article is part of a Special Issue entitled 'Synaptic Plasticity & Interneurons'.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1873-7064
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
720-9
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Induction and expression rules of synaptic plasticity in hippocampal interneurons.
pubmed:affiliation
University Texas Medical Branch, Department of Pharmacology & Toxicology, 301 University Boulevard, Galveston, TX 77555, USA. felaezza@utmb.edu
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural