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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-1-31
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pubmed:abstractText |
Adiponectin exerts anti-diabetic and anti-atherogenesis properties through its 2 receptors (AdipoR1 and AdipoR2). However, the signaling pathways responsible for the anti-inflammatory effects of adiponectin are largely unknown. In this study, we identified the lymphotoxin (LT)-? receptor (LTBR) as an interacting partner of human AdipoR1 by using a yeast two-hybrid screening. The interaction between LTBR and AdipoR1 was confirmed by co-immunoprecipitation and co-localization analysis. Furthermore, adiponectin incubation inhibited lymphotoxin-induced NF-?B activation and the expression of adhesion molecules in human umbilical vein endothelial cells. These results indicated that AdipoR1 interacted with LTBR and mediated the inhibition of LTBR-activated NF-?B pathway.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1090-2104
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
28
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pubmed:volume |
404
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1060-4
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pubmed:meshHeading |
pubmed-meshheading:21195057-Adiponectin,
pubmed-meshheading:21195057-Animals,
pubmed-meshheading:21195057-COS Cells,
pubmed-meshheading:21195057-Cercopithecus aethiops,
pubmed-meshheading:21195057-Endothelium, Vascular,
pubmed-meshheading:21195057-Humans,
pubmed-meshheading:21195057-Immunoprecipitation,
pubmed-meshheading:21195057-Lymphotoxin alpha1, beta2 Heterotrimer,
pubmed-meshheading:21195057-Lymphotoxin beta Receptor,
pubmed-meshheading:21195057-NF-kappa B,
pubmed-meshheading:21195057-Receptors, Adiponectin,
pubmed-meshheading:21195057-Two-Hybrid System Techniques,
pubmed-meshheading:21195057-Umbilical Veins
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pubmed:year |
2011
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pubmed:articleTitle |
Adiponectin inhibits lymphotoxin-? receptor-mediated NF-?B signaling in human umbilical vein endothelial cells.
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pubmed:affiliation |
Department of Cardiology, Hangzhou the First People's Hospital, Hangzhou Hospital of Nanjing Medical University, Hangzhou 310006, China. xuyizhou5@gmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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