Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1990-10-24
|
| pubmed:abstractText |
In this study, we examined the effect of injecting various cytokines. We report here that tumour necrosis factor (TNF)alpha, gamma-interferon and interleukin 2 (IL-2) can, in some circumstances, increase fetal resorption rates in abortion-prone (CBA/J x DBA/2) and non-abortion prone (CBA/J x BALB/c,C3H x DBA/2) matings: 1000 units TNF enhanced resorptions from 43 to 79% in CBA x DBA/2, from 7 to 89% in CBA x BALB/c, from 5 to 47% in C3H x DBA/2. The effect was both gestational age- and dose-dependent. Gamma interferon and R-IL-2 enhanced resorptions from 38 to 68% and 76% respectively in the CBA/J x DBA/2 mating combination, whereas the rates in CBA/J x BALB/c matings were enhanced from 6 to 44% and 55%. Lipopolysaccharide (LPS), which is known to lead to the release of TNF-alpha, had a similar effect, leading to gestational age- and dose-dependent enhancement of resorptions up to 100%. However, cytokines of the CSF family, including IL-3 and GM-CSF, increased the chances of fetal survival when injected into abortion-prone mice, e.g. reducing resorption rates in the abortion-prone CBA/J x DBA/2 mating combination from 55 to 22% (IL-3), and 47 to 8% (GM-CSF). They also increased fetal and placental weight and, in particular, expanded the spongiotrophoblast zone in the placenta. The latter observations may be due to a direct trophic influence on placental cells, perhaps through a cytokine cascade, or an indirect effect due to inhibition of natural killer (NK)-like cells, or both. Whatever the mechanism, these results may find practical application in influencing reproductive outcome in women and other species.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Colony-Stimulating Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte-Macrophage...,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-3,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0022-4251
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
89
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
447-58
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:2119428-Animals,
pubmed-meshheading:2119428-Colony-Stimulating Factors,
pubmed-meshheading:2119428-Female,
pubmed-meshheading:2119428-Fetal Death,
pubmed-meshheading:2119428-Fetal Resorption,
pubmed-meshheading:2119428-Fetus,
pubmed-meshheading:2119428-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:2119428-Growth Substances,
pubmed-meshheading:2119428-Interferon-gamma,
pubmed-meshheading:2119428-Interleukin-2,
pubmed-meshheading:2119428-Interleukin-3,
pubmed-meshheading:2119428-Lymphokines,
pubmed-meshheading:2119428-Mice,
pubmed-meshheading:2119428-Mice, Inbred BALB C,
pubmed-meshheading:2119428-Mice, Inbred C3H,
pubmed-meshheading:2119428-Mice, Inbred CBA,
pubmed-meshheading:2119428-Mice, Inbred DBA,
pubmed-meshheading:2119428-Placenta,
pubmed-meshheading:2119428-Pregnancy,
pubmed-meshheading:2119428-Tumor Necrosis Factor-alpha
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Control of fetal survival in CBA x DBA/2 mice by lymphokine therapy.
|
| pubmed:affiliation |
U 262 INSERM, Clinique Universitaire Baudelocque, Paris, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|