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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1990-10-26
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pubmed:abstractText |
The 5-HT-induced inward current in rat facial motoneurons was rendered irreversible by intracellular GTP gamma S, an hydrolysis-resistant analog of guanosine 5'-triphosphate which sustains G protein activation. Conversely, the 5-HT response was reduced by GDP beta S, an analog of guanosine 5'-diphosphate which interferes with G protein activation. Inhibitors of protein kinase C enhanced the 5-HT-induced inward current. Thus, the slow inward current induced by 5-HT in facial motoneurons appears to be mediated by G proteins but modulated negatively by protein kinase C.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-(5-Isoquinolinesulfonyl)-2-Methylp...,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Guanosine 5'-O-(3-Thiotriphosphate),
http://linkedlifedata.com/resource/pubmed/chemical/Guanosine Diphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Guanosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Isoquinolines,
http://linkedlifedata.com/resource/pubmed/chemical/Phorbol Esters,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Thionucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/guanosine 5'-O-(2-thiodiphosphate),
http://linkedlifedata.com/resource/pubmed/chemical/phorbol-12,13-diacetate
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
524
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
171-4
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:2119243-1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine,
pubmed-meshheading:2119243-Animals,
pubmed-meshheading:2119243-Brain,
pubmed-meshheading:2119243-Electric Conductivity,
pubmed-meshheading:2119243-Facial Nerve,
pubmed-meshheading:2119243-GTP-Binding Proteins,
pubmed-meshheading:2119243-Guanosine 5'-O-(3-Thiotriphosphate),
pubmed-meshheading:2119243-Guanosine Diphosphate,
pubmed-meshheading:2119243-Guanosine Triphosphate,
pubmed-meshheading:2119243-Isoquinolines,
pubmed-meshheading:2119243-Male,
pubmed-meshheading:2119243-Motor Neurons,
pubmed-meshheading:2119243-Phorbol Esters,
pubmed-meshheading:2119243-Piperazines,
pubmed-meshheading:2119243-Protein Kinase C,
pubmed-meshheading:2119243-Rats,
pubmed-meshheading:2119243-Serotonin,
pubmed-meshheading:2119243-Thionucleotides
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pubmed:year |
1990
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pubmed:articleTitle |
Serotonin-induced inward current in rat facial motoneurons: evidence for mediation by G proteins but not protein kinase C.
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pubmed:affiliation |
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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