rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1990-10-19
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pubmed:abstractText |
LPS-stimulated macrophage conditioned medium and IL-6 markedly stimulated the secretion of PSTI by cultured hepatoblastoma cells. The mechanism underlying the cellular response of IL-6-induced secretion of PSTI was investigated. Among the agents affecting the signal transduction pathways, forskolin significantly induced PSTI secretion whereas PMA or A23187 did not, suggesting that IL-6 induced PSTI secretion is mediated by cAMP dependent protein kinase A.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biological Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Calcimycin,
http://linkedlifedata.com/resource/pubmed/chemical/Cycloheximide,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Forskolin,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/Trypsin Inhibitor, Kazal Pancreatic,
http://linkedlifedata.com/resource/pubmed/chemical/Trypsin Inhibitors
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0177-3593
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
371 Suppl
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
95-100
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2119190-Animals,
pubmed-meshheading:2119190-Biological Factors,
pubmed-meshheading:2119190-Calcimycin,
pubmed-meshheading:2119190-Cycloheximide,
pubmed-meshheading:2119190-Cytokines,
pubmed-meshheading:2119190-Forskolin,
pubmed-meshheading:2119190-Humans,
pubmed-meshheading:2119190-Interleukin-6,
pubmed-meshheading:2119190-Lipopolysaccharides,
pubmed-meshheading:2119190-Liver Neoplasms, Experimental,
pubmed-meshheading:2119190-Lymphocyte Activation,
pubmed-meshheading:2119190-Tetradecanoylphorbol Acetate,
pubmed-meshheading:2119190-Trypsin Inhibitor, Kazal Pancreatic,
pubmed-meshheading:2119190-Trypsin Inhibitors,
pubmed-meshheading:2119190-Tumor Cells, Cultured
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pubmed:year |
1990
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pubmed:articleTitle |
Response to IL-6 stimulation of human hepatoblastoma cells: production of pancreatic secretory trypsin inhibitor.
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pubmed:affiliation |
Second Department of Surgery, Osaka University Medical School, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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