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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-4-28
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pubmed:abstractText |
P-glycoprotein (P-gp) plays an important role in the efflux of drugs from the brain back into the bloodstream and can influence the pharmacokinetics and pharmacodynamics of drug molecules. To our knowledge, no studies have reported pharmacodynamic effects of any antidepressant drug in the P-gp knockout mice model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1432-2072
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
215
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
367-77
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pubmed:meshHeading |
pubmed-meshheading:21191569-Analysis of Variance,
pubmed-meshheading:21191569-Animals,
pubmed-meshheading:21191569-Antidepressive Agents, Second-Generation,
pubmed-meshheading:21191569-Blood-Brain Barrier,
pubmed-meshheading:21191569-Cyclohexanols,
pubmed-meshheading:21191569-Dose-Response Relationship, Drug,
pubmed-meshheading:21191569-Exploratory Behavior,
pubmed-meshheading:21191569-Male,
pubmed-meshheading:21191569-Mice,
pubmed-meshheading:21191569-Mice, Knockout,
pubmed-meshheading:21191569-Motor Activity,
pubmed-meshheading:21191569-P-Glycoprotein,
pubmed-meshheading:21191569-Stereoisomerism,
pubmed-meshheading:21191569-Time Factors
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pubmed:year |
2011
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pubmed:articleTitle |
Effects on enantiomeric drug disposition and open-field behavior after chronic treatment with venlafaxine in the P-glycoprotein knockout mice model.
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pubmed:affiliation |
Division of Drug Research, Clinical Pharmacology, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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