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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-1-11
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pubmed:abstractText |
The inhibition of the Hedgehog (Hh) signaling pathway has emerged as an anti-cancer strategy. Three flavonoid glycosides including 2 new compounds (1-2) were isolated from Excoecaria agallocha as Hedgehog/GLI1-mediated transcriptional inhibitors and exhibited cytotoxicity against human pancreatic (PANC1) and prostate (DU145) cancer cells. Our data revealed that compound 1 clearly inhibited the expression of GLI-related proteins (PTCH and BCL-2) and blocked the translocation of GLI1 transcription factors into the nucleus in PANC1. Deleting the Smoothened (Smo) function in PANC1 treated with 1 led to downregulation of the mRNA expression of Ptch. This study describes the first Hh signaling inhibitor which blocks GLI1 movement into the nucleus without interfering with Smo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic,
http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids,
http://linkedlifedata.com/resource/pubmed/chemical/GLI1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Glycosides,
http://linkedlifedata.com/resource/pubmed/chemical/Hedgehog Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/patched receptors
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
718-22
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pubmed:meshHeading |
pubmed-meshheading:21190854-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:21190854-Cell Line, Tumor,
pubmed-meshheading:21190854-Cell Survival,
pubmed-meshheading:21190854-Euphorbiaceae,
pubmed-meshheading:21190854-Flavonoids,
pubmed-meshheading:21190854-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:21190854-Glycosides,
pubmed-meshheading:21190854-Hedgehog Proteins,
pubmed-meshheading:21190854-Humans,
pubmed-meshheading:21190854-Male,
pubmed-meshheading:21190854-Neoplasms,
pubmed-meshheading:21190854-Pancreatic Neoplasms,
pubmed-meshheading:21190854-Prostatic Neoplasms,
pubmed-meshheading:21190854-Receptors, Cell Surface,
pubmed-meshheading:21190854-Signal Transduction,
pubmed-meshheading:21190854-Transcription Factors,
pubmed-meshheading:21190854-Transcriptional Activation
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pubmed:year |
2011
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pubmed:articleTitle |
New Hedgehog/GLI signaling inhibitors from Excoecaria agallocha.
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pubmed:affiliation |
Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263-8522, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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