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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2011-1-21
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pubmed:abstractText |
Diabetes mellitus counts as a major risk factor for developing atherosclerosis. The activation of protein kinase C (PKC) is commonly known to take a pivotal part in the pathogenesis of atherosclerosis, though the influence of specific PKC isozymes remains unclear. There is evidence from large clinical trials suggesting excessive neurohumoral stimulation, amongst other pathways leading to PKC activation, as a central mechanism in the pathogenesis of diabetic heart disease. The present study was therefore designed to determine the role of Gq-protein signalling via G?11 in diabetes for the expression of PKC isozymes in the coronary vessels.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21190563-10571782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21190563-10747353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21190563-10783893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21190563-10865832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21190563-11009455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21190563-11230335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21190563-11689889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21190563-11709417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21190563-11914250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21190563-11937179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21190563-12000746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21190563-12055197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21190563-16317525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21190563-16892061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21190563-16894036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21190563-16930534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21190563-16987994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21190563-18497307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21190563-19210763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21190563-2655581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21190563-7631740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21190563-7989608,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/21190563-8620597,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/21190563-9887982
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Protein alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Prkca protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Prkcd protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Prkce protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C-delta,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C-epsilon,
http://linkedlifedata.com/resource/pubmed/chemical/protein kinase C beta,
http://linkedlifedata.com/resource/pubmed/chemical/protein kinase C zeta
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pubmed:status |
MEDLINE
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pubmed:issn |
1475-2840
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
93
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pubmed:dateRevised |
2011-7-20
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pubmed:meshHeading |
pubmed-meshheading:21190563-Animals,
pubmed-meshheading:21190563-Blood Glucose,
pubmed-meshheading:21190563-Coronary Vessels,
pubmed-meshheading:21190563-Diabetes Mellitus, Experimental,
pubmed-meshheading:21190563-Diabetes Mellitus, Type 1,
pubmed-meshheading:21190563-GTP-Binding Protein alpha Subunits, Gq-G11,
pubmed-meshheading:21190563-Immunohistochemistry,
pubmed-meshheading:21190563-Isoenzymes,
pubmed-meshheading:21190563-Mice,
pubmed-meshheading:21190563-Mice, Inbred C57BL,
pubmed-meshheading:21190563-Mice, Knockout,
pubmed-meshheading:21190563-Protein Kinase C,
pubmed-meshheading:21190563-Protein Kinase C-alpha,
pubmed-meshheading:21190563-Protein Kinase C-delta,
pubmed-meshheading:21190563-Protein Kinase C-epsilon,
pubmed-meshheading:21190563-Time Factors
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pubmed:year |
2010
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pubmed:articleTitle |
Differential expression of protein kinase C isoforms in coronary arteries of diabetic mice lacking the G-protein G?11.
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pubmed:affiliation |
Department of Internal Medicine III, University of Cologne, Kerpener Str, 62, 50937 Cologne, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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