Source:http://linkedlifedata.com/resource/pubmed/id/21190352
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2011-1-31
|
| pubmed:abstractText |
Clostridium difficile is the most commonly diagnosed cause of nosocomial diarrhea with increasing incidence and mortality among elderly and hospitalized patients. We report the first synthesis of the surface polysaccharide PS-II repeating unit and its nonphosphorylated analogue, with a linker for conjugation, via a (4 + 2) convergent approach from a common AB(D)C tetrasaccharide intermediate.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1523-7052
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
4
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
378-81
|
| pubmed:meshHeading |
pubmed-meshheading:21190352-Aged,
pubmed-meshheading:21190352-Carbohydrate Sequence,
pubmed-meshheading:21190352-Cell Wall,
pubmed-meshheading:21190352-Clostridium difficile,
pubmed-meshheading:21190352-Diarrhea,
pubmed-meshheading:21190352-Humans,
pubmed-meshheading:21190352-Polysaccharides, Bacterial
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
First synthesis of C. difficile PS-II cell wall polysaccharide repeating unit.
|
| pubmed:affiliation |
Novartis Vaccines & Diagnostics, Vaccine Chemistry Department, Via Fiorentina 1, 53100 Siena, Italy.
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| pubmed:publicationType |
Journal Article
|