Linked Life Data

21187599

Source:http://linkedlifedata.com/resource/pubmed/id/21187599

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-12-28
pubmed:abstractText
Calcium-sensing receptor (CaSR) is a G protein-coupled receptor which was identified as a molecule that medicates the suppression of parathyroid hormone (PTH) secretion by extracellular Ca. Calcilytics are chemicals that enhance PTH secretion by antagonizing CaSR. JTT-305/MK-5442 is one of calcilytics made in Japan and is considered to be used as a bone anabolic agent through its stimulatory effect on PTH secretion. It is reported that JTT-305/MK-5442 increased lumbar bone mineral density by a placebo-controlled trial. However, further studies with more subjects are necessary to establish the clinical utility of JTT-305/MK-5442.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0917-5857
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
89-93
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
[Antagonist for calcium-sensing receptor. JTT-305/MK-5442].
pubmed:affiliation
Division of Nephrology & Endocrinology, Department of Medicine, University of Tokyo Hospital.
pubmed:publicationType
Journal Article, English Abstract, Review