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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-4-19
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pubmed:abstractText |
n-3 Polyunsaturated fatty acids (PUFAs) are known to protect the cardiovascular system and improve blood pressure control. These important dietary constituents are converted into bioactive metabolites, but their role in regulation of the cardiovascular system is unclear. In particular, the functions of the cytochrome P450 (CYP) metabolites of n-3 PUFAs remain virtually unexplored. In this study, we examined the effects of docosahexaenoic acid (DHA) on the regulation of large-conductance calcium-activated potassium (BK) channel activities in coronary arterial smooth muscle cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1755-3245
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
344-52
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pubmed:meshHeading |
pubmed-meshheading:21187320-Animals,
pubmed-meshheading:21187320-Coronary Vessels,
pubmed-meshheading:21187320-Cytochrome P-450 Enzyme System,
pubmed-meshheading:21187320-Docosahexaenoic Acids,
pubmed-meshheading:21187320-Enzyme Inhibitors,
pubmed-meshheading:21187320-Large-Conductance Calcium-Activated Potassium Channels,
pubmed-meshheading:21187320-Muscle, Smooth, Vascular,
pubmed-meshheading:21187320-Patch-Clamp Techniques,
pubmed-meshheading:21187320-Peptides,
pubmed-meshheading:21187320-Potassium,
pubmed-meshheading:21187320-Proadifen,
pubmed-meshheading:21187320-Rats,
pubmed-meshheading:21187320-Rats, Sprague-Dawley,
pubmed-meshheading:21187320-Vasodilation
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pubmed:year |
2011
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pubmed:articleTitle |
Activation of vascular BK channels by docosahexaenoic acid is dependent on cytochrome P450 epoxygenase activity.
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pubmed:affiliation |
Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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