Linked Life Data

21186260

Source:http://linkedlifedata.com/resource/pubmed/id/21186260

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2011-1-6
pubmed:abstractText
Functional characteristics of tuberculosis (TB)-specific CD4 T cells were studied in clinically active pulmonary TB (n?=?21) and high TB exposure including LTBI (n?=?17). Following tuberculin stimulation, activated CD4 T cells were identified by flow-cytometry (CD154 up-regulation, degranulation, interferon ? [IFN-?], tumor necrosis factor ? [TNF-?], and interleukin 2 [IL-2\ production). Interestingly, CD154 up-regulation accounted for ?80% of activated CD4 T cells in the active TB group but just 40% in the controls, whereas IFN-? accounted for only ?50% of activated cells in each group. The frequencies of CD4 T cells displaying at least 1 activation marker discriminated better between the groups than those displaying degranulation or IFN-? production alone.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1537-6613
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
203
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
378-82
pubmed:dateRevised
2011-8-4
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Tuberculin-specific T cells are reduced in active pulmonary tuberculosis compared to LTBI or status post BCG vaccination.
pubmed:affiliation
Institut für Medizinische Immunologie, Charité - Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't