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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1990-10-10
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pubmed:abstractText |
To examine the role of neuropeptide Y (NPY) in the first luteinizing hormone (LH) surge of puberty, the effect of passive immunoneutralization of NPY with antiserum against NPY (anti-NPY) injected centrally (third ventricle) or peripherally (jugular vein) was studied in pubertal female rats on the day of first proestrus. Both peripheral and central anti-NPY administration reduced the magnitude of the LH surge during the afternoon of first proestrus; however, the central route of administration appeared to be most effective. Centrally administered anti-NPY also reduced the magnitude of proestrous LH-releasing hormone (LHRH) release into pituitary portal blood in these rats. These results suggest that endogenous NPY plays a facilitatory role in the generation of the LHRH surge necessary for preovulatory gonadotropin release and puberty.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0028-3835
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
112-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2118604-Animals,
pubmed-meshheading:2118604-Female,
pubmed-meshheading:2118604-Gonadotropin-Releasing Hormone,
pubmed-meshheading:2118604-Immune Sera,
pubmed-meshheading:2118604-Luteinizing Hormone,
pubmed-meshheading:2118604-Neuropeptide Y,
pubmed-meshheading:2118604-Ovulation Induction,
pubmed-meshheading:2118604-Rats,
pubmed-meshheading:2118604-Rats, Inbred Strains,
pubmed-meshheading:2118604-Sexual Maturation
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pubmed:year |
1990
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pubmed:articleTitle |
Facilitatory role of neuropeptide Y on the onset of puberty: effect of immunoneutralization of neuropeptide Y on the release of luteinizing hormone and luteinizing-hormone-releasing hormone.
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pubmed:affiliation |
Department of Veterinary and Comparative Anatomy, Washington State University, Pullman.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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