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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-3-29
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pubmed:abstractText |
The transient receptor potential (TRP) channels TRPV1 and TRPA1 have each been associated with regulation of efferent properties of primary afferent neurons that initiate neurogenic inflammation and are required for the development of inflammatory hyperalgesia. To evaluate the role of these channels in producing pain during pancreatic inflammation, we studied pancreatic nodose ganglion (NG) and dorsal root ganglion (DRG) sensory neurons (identified by content of retrograde tracer) and behavioral outcomes in a mouse model of acute pancreatitis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-te...,
http://linkedlifedata.com/resource/pubmed/chemical/3-(4-t-butylphenyl)-N-(2,3-dihydrobe...,
http://linkedlifedata.com/resource/pubmed/chemical/ANKTM1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Acetanilides,
http://linkedlifedata.com/resource/pubmed/chemical/Acrylamides,
http://linkedlifedata.com/resource/pubmed/chemical/Bicyclo Compounds, Heterocyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Purines,
http://linkedlifedata.com/resource/pubmed/chemical/TRPV Cation Channels,
http://linkedlifedata.com/resource/pubmed/chemical/TRPV1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transient Receptor Potential...
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1528-0012
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
140
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1283-1291.e1-2
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pubmed:meshHeading |
pubmed-meshheading:21185837-Abdominal Pain,
pubmed-meshheading:21185837-Acetanilides,
pubmed-meshheading:21185837-Acrylamides,
pubmed-meshheading:21185837-Acute Disease,
pubmed-meshheading:21185837-Animals,
pubmed-meshheading:21185837-Behavior, Animal,
pubmed-meshheading:21185837-Bicyclo Compounds, Heterocyclic,
pubmed-meshheading:21185837-Calcium,
pubmed-meshheading:21185837-Cells, Cultured,
pubmed-meshheading:21185837-Disease Models, Animal,
pubmed-meshheading:21185837-Ganglia, Spinal,
pubmed-meshheading:21185837-Gene Expression,
pubmed-meshheading:21185837-Male,
pubmed-meshheading:21185837-Mice,
pubmed-meshheading:21185837-Mice, Inbred C57BL,
pubmed-meshheading:21185837-Nodose Ganglion,
pubmed-meshheading:21185837-Pancreas,
pubmed-meshheading:21185837-Pancreatitis,
pubmed-meshheading:21185837-Patch-Clamp Techniques,
pubmed-meshheading:21185837-Purines,
pubmed-meshheading:21185837-TRPV Cation Channels,
pubmed-meshheading:21185837-Transient Receptor Potential Channels
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pubmed:year |
2011
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pubmed:articleTitle |
Synergistic role of TRPV1 and TRPA1 in pancreatic pain and inflammation.
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pubmed:affiliation |
Center for Pain Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. schwartzee@upmc.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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