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rdf:type |
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lifeskim:mentions |
umls-concept:C0005955,
umls-concept:C0007600,
umls-concept:C0033414,
umls-concept:C0085424,
umls-concept:C0205307,
umls-concept:C0591833,
umls-concept:C0887899,
umls-concept:C1514485,
umls-concept:C1516960,
umls-concept:C1522492,
umls-concept:C1533691,
umls-concept:C2349975
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pubmed:issue |
5
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pubmed:dateCreated |
1990-10-5
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|
pubmed:abstractText |
T-cell growth factor P40 was examined for possible effects on murine interleukin-3 (IL-3)-dependent myeloid cell lines and freshly isolated murine bone marrow cells. The results showed that P40 stimulated the proliferation of some IL-3-dependent myeloid cell lines of both early myeloid and mast cell phenotype and synergized with IL-3. P40 did not promote proliferation of fresh bone marrow cells, bone marrow enriched for early myeloid cells by 5-fluorouracil treatment, or bone marrow derived mast cells as assessed in 3H-TdR incorporation assays. P40 did not influence the growth of murine colony-forming unit granulocyte-macrophage in agar cultures, either alone or in the presence of optimal or sub-optimal concentrations of CSF-1, GM-colony-stimulating factor, or IL-3. P40 did potentiate burst-forming unit-erythroid (BFU-E) formation in the presence of erythropoietin; however, this was dependent on the cell plating density, suggesting an indirect stimulation of BFU-E by P40. The indirect nature of P40 action on BFU-E was further demonstrated in cell separation experiments and indicated that the effect was mediated by T cells. These data expand the repertoire of cells that P40 influences.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0006-4971
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
906-11
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:2118397-Animals,
pubmed-meshheading:2118397-Base Sequence,
pubmed-meshheading:2118397-Bone Marrow Cells,
pubmed-meshheading:2118397-Cell Division,
pubmed-meshheading:2118397-Cell Line,
pubmed-meshheading:2118397-Colony-Stimulating Factors,
pubmed-meshheading:2118397-Erythrocytes,
pubmed-meshheading:2118397-Erythropoietin,
pubmed-meshheading:2118397-Female,
pubmed-meshheading:2118397-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:2118397-Growth Substances,
pubmed-meshheading:2118397-Hematopoietic Stem Cells,
pubmed-meshheading:2118397-Interleukin-3,
pubmed-meshheading:2118397-Interleukin-9,
pubmed-meshheading:2118397-Interleukins,
pubmed-meshheading:2118397-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:2118397-Mice,
pubmed-meshheading:2118397-Mice, Inbred C57BL,
pubmed-meshheading:2118397-Mice, Inbred Strains,
pubmed-meshheading:2118397-Molecular Sequence Data,
pubmed-meshheading:2118397-Oligonucleotide Probes,
pubmed-meshheading:2118397-Polymerase Chain Reaction,
pubmed-meshheading:2118397-Recombinant Proteins
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pubmed:year |
1990
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pubmed:articleTitle |
T-cell growth factor P40 promotes the proliferation of myeloid cell lines and enhances erythroid burst formation by normal murine bone marrow cells in vitro.
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pubmed:affiliation |
Department of Experimental Hematology, Immunex Corporation, Seattle, WA 98101.
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pubmed:publicationType |
Journal Article
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