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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-4-19
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pubmed:abstractText |
Ligand activation of peroxisome proliferator-activated receptors (PPARs) prevents cardiomyocyte hypertrophy, but the underlying signalling mechanisms remain unknown. We previously reported that the anti-hypertrophic effect of the dietary polyunsaturated fatty acid, conjugated linoleic acid (CLA), was associated with the upregulation of diacylglycerol (DAG) kinase (DGK). DGK catalyses phosphorylative conversion/attenuation of DAG, thereby modulating protein kinase C (PKC) and G-protein signalling. As the anti-hypertrophic effects of CLA were attenuated by inhibitors of PPARs, the present aim was to investigate the involvement of DGK in the anti-hypertrophic actions of bona fide selective PPAR agonists.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chromans,
http://linkedlifedata.com/resource/pubmed/chemical/Diacylglycerol Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Fenofibrate,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Hypolipidemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Peroxisome Proliferator-Activated...,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazolidinediones,
http://linkedlifedata.com/resource/pubmed/chemical/diacylglycerol kinase zeta, rat,
http://linkedlifedata.com/resource/pubmed/chemical/troglitazone
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1755-3245
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
267-75
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pubmed:meshHeading |
pubmed-meshheading:21183507-Age Factors,
pubmed-meshheading:21183507-Animals,
pubmed-meshheading:21183507-Animals, Newborn,
pubmed-meshheading:21183507-Cardiomegaly,
pubmed-meshheading:21183507-Cells, Cultured,
pubmed-meshheading:21183507-Chromans,
pubmed-meshheading:21183507-Diacylglycerol Kinase,
pubmed-meshheading:21183507-Endothelin-1,
pubmed-meshheading:21183507-Fenofibrate,
pubmed-meshheading:21183507-Hypoglycemic Agents,
pubmed-meshheading:21183507-Hypolipidemic Agents,
pubmed-meshheading:21183507-Myocytes, Cardiac,
pubmed-meshheading:21183507-Peroxisome Proliferator-Activated Receptors,
pubmed-meshheading:21183507-Rats,
pubmed-meshheading:21183507-Rats, Sprague-Dawley,
pubmed-meshheading:21183507-Signal Transduction,
pubmed-meshheading:21183507-Thiazolidinediones,
pubmed-meshheading:21183507-Up-Regulation
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pubmed:year |
2011
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pubmed:articleTitle |
Suppression of endothelin-1-induced cardiac myocyte hypertrophy by PPAR agonists: role of diacylglycerol kinase zeta.
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pubmed:affiliation |
Canadian Centre for Agri-Food Research in Health and Medicine, St Boniface General Hospital Research Centre, Manitoba, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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