Linked Life Data

21183275

Source:http://linkedlifedata.com/resource/pubmed/id/21183275

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-1-17
pubmed:abstractText
Thyroid hormones (TH) - 3,5,3'-triiodo-L-thyronine (T?) and l-thyroxine (T?) - are important regulators of differentiation, growth, metabolism, and physiological function in most tissues. TH have been also implicated in cellular transformation, tumorigenesis and metastasis, assuming particular importance in tumor induced angiogenesis. TH-induced angiogenesis is thought to be initiated at integrin ?v?3 membrane receptor mainly through T? binding. The reduction of TH in circulation or the inhibition of TH actions at the integrin ?v?3 receptor would consequently produce a reduction on the proliferative and angiogenic TH effects. Therefore, targeting TH actions could be an alternative adjuvant therapy against cancer proliferation and angiogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1872-7980
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
28
pubmed:volume
301
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
119-26
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Thyroid hormone as a regulator of tumor induced angiogenesis.
pubmed:affiliation
Institute of Molecular Pathology and Immunology of the University of Porto, Portugal.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't