Source:http://linkedlifedata.com/resource/pubmed/id/21182081
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2010-12-24
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pubmed:abstractText |
HIV-1 mutants escaping from HLA-A- or HLA-B-restricted CTL have been well studied, but those from HLA-C-restricted CTL have not. Therefore we investigated the ability of HLA-C-restricted CTL to select HIV-1 escape mutants. In the present study, we identified two novel HLA-Cw(*) 1202-restricted Pol-specific CTL epitopes (Pol328-9 and Pol463-10). CTL specific for these epitopes were detected in 25-40% of chronically HIV-1-infected HLA-Cw(*) 1202(+) individuals and had strong abilities to kill HIV-1-infected cells and to suppress HIV-1 replication in vitro, suggesting that these CTL may have the ability to effectively control HIV-1 in some HLA-Cw(*) 1202(+) individuals. Sequence analysis of these epitopes showed that a V-to-A substitution at the 9th position (V9A) of Pol 463-10 was significantly associated with the HLA-Cw(*) 1202 allele and that the V9A mutant was slowly selected in the HLA-Cw(*) 1202(+) individuals. Pol 463-10-specific CTL failed both to kill the V9A virus-infected cells and to suppress replication of the V9A mutant. These results indicate that the V9A mutation was selected as an escape mutant by the Pol463-10-specific CTL. The present study strongly suggests that some HLA-C-restricted CTL have a strong ability to suppress HIV-1 replication so that they can select HIV escape mutants as in the case of HLA-A-restricted or HLA-B-restricted CTL.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1521-4141
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pubmed:author |
pubmed-author:BorghanMohamed AliMA,
pubmed-author:ChikataTakayukiT,
pubmed-author:GatanagaHiroyukiH,
pubmed-author:HashimotoMasaoM,
pubmed-author:HondaKazutakaK,
pubmed-author:KoyanagiMadokaM,
pubmed-author:MurakoshiHayatoH,
pubmed-author:OkaShinichiS,
pubmed-author:SakaiKeikoK,
pubmed-author:TakiguchiMasafumiM,
pubmed-author:TamuraYoshikoY,
pubmed-author:ZhengNanN
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pubmed:copyrightInfo |
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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pubmed:issnType |
Electronic
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
97-106
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pubmed:meshHeading |
pubmed-meshheading:21182081-Amino Acid Sequence,
pubmed-meshheading:21182081-Epitopes, T-Lymphocyte,
pubmed-meshheading:21182081-HIV Infections,
pubmed-meshheading:21182081-HIV-1,
pubmed-meshheading:21182081-HLA-C Antigens,
pubmed-meshheading:21182081-Humans,
pubmed-meshheading:21182081-Immune Evasion,
pubmed-meshheading:21182081-Molecular Sequence Data,
pubmed-meshheading:21182081-Mutation,
pubmed-meshheading:21182081-Selection, Genetic,
pubmed-meshheading:21182081-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:21182081-Virus Replication,
pubmed-meshheading:21182081-pol Gene Products, Human Immunodeficiency Virus
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pubmed:year |
2011
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pubmed:articleTitle |
Selection of escape mutant by HLA-C-restricted HIV-1 Pol-specific cytotoxic T lymphocytes carrying strong ability to suppress HIV-1 replication.
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pubmed:affiliation |
Center for AIDS Research, Kumamoto University, Honjo, Kumamoto, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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