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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2010-12-23
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pubmed:abstractText |
IFN-? and IL-2 cytokine-profiles define three functional T-cell subsets which may correlate with pathogen load in chronic intracellular infections. We therefore investigated the feasibility of the immunospot platform to rapidly enumerate T-cell subsets by single-cell IFN-?/IL-2 cytokine-profiling and establish whether immunospot-based T-cell signatures distinguish different clinical stages of human tuberculosis infection.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
pubmed-author:BlumenkrantzDeenaD,
pubmed-author:BremangSamuelS,
pubmed-author:CaseyRosalynR,
pubmed-author:ConnellDavidD,
pubmed-author:KonOnn MinOM,
pubmed-author:LalvaniAjitA,
pubmed-author:MagtotoMurphyM,
pubmed-author:MillingtonKerryK,
pubmed-author:Montamat-SicotteDamienD,
pubmed-author:SridharSaranyaS,
pubmed-author:WickremasingheMelissaM
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e15619
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pubmed:meshHeading |
pubmed-meshheading:21179481-Adolescent,
pubmed-meshheading:21179481-Adult,
pubmed-meshheading:21179481-Aged,
pubmed-meshheading:21179481-Case-Control Studies,
pubmed-meshheading:21179481-Cell Count,
pubmed-meshheading:21179481-Cross-Sectional Studies,
pubmed-meshheading:21179481-Female,
pubmed-meshheading:21179481-Flow Cytometry,
pubmed-meshheading:21179481-Humans,
pubmed-meshheading:21179481-Interferon-gamma,
pubmed-meshheading:21179481-Interleukin-2,
pubmed-meshheading:21179481-Male,
pubmed-meshheading:21179481-Microscopy, Fluorescence,
pubmed-meshheading:21179481-Middle Aged,
pubmed-meshheading:21179481-Mycobacterium tuberculosis,
pubmed-meshheading:21179481-Risk Factors,
pubmed-meshheading:21179481-T-Lymphocytes,
pubmed-meshheading:21179481-Tuberculosis
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pubmed:year |
2010
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pubmed:articleTitle |
Enumeration of functional T-cell subsets by fluorescence-immunospot defines signatures of pathogen burden in tuberculosis.
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pubmed:affiliation |
Tuberculosis Research Unit, Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, St Mary's Hospital, London, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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