rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2010-12-23
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pubmed:abstractText |
Interleukin-6 (IL-6) is a pro-inflammatory cytokine that has been found to be increased in type 2 diabetic subjects. However, it still remains unclear if these elevated IL-6 levels are co-incidental or if this cytokine is causally related to the development of insulin resistance and type 2 diabetes in humans. Therefore, in the present study we examined insulin sensitivity, serum adipokine levels and lipid parameters in human subjects before and after treatment with the IL-6 receptor antibody Tocilizumab.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adipokines,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal, Humanized,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoprotein(a),
http://linkedlifedata.com/resource/pubmed/chemical/tocilizumab
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e14328
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:21179199-Adipokines,
pubmed-meshheading:21179199-Adult,
pubmed-meshheading:21179199-Aged,
pubmed-meshheading:21179199-Antibodies, Monoclonal,
pubmed-meshheading:21179199-Antibodies, Monoclonal, Humanized,
pubmed-meshheading:21179199-Arthritis, Rheumatoid,
pubmed-meshheading:21179199-Cytokines,
pubmed-meshheading:21179199-Diabetes Mellitus, Type 2,
pubmed-meshheading:21179199-Female,
pubmed-meshheading:21179199-Humans,
pubmed-meshheading:21179199-Insulin,
pubmed-meshheading:21179199-Insulin Resistance,
pubmed-meshheading:21179199-Interleukin-6,
pubmed-meshheading:21179199-Lipoprotein(a),
pubmed-meshheading:21179199-Male,
pubmed-meshheading:21179199-Middle Aged,
pubmed-meshheading:21179199-Signal Transduction
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pubmed:year |
2010
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pubmed:articleTitle |
Effects of inhibition of interleukin-6 signalling on insulin sensitivity and lipoprotein (a) levels in human subjects with rheumatoid diseases.
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pubmed:affiliation |
Department of Internal Medicine II and Centre of Molecular Medicine Cologne, University of Cologne, Cologne, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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