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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-1-21
pubmed:abstractText
Multiple genetic and environmental factors underlie the etiology of type 2 diabetes. To evaluate the influence of the relationship between dietary fat intake and single nucleotide polymorphisms (SNPs) in genes involved in fat assimilation on disease susceptibility, a 2-step approach using an exploratory case-control study (n = 192/384) and an independent, confirmatory case-cohort study (n = 614/2248) taken from the same prospective study population (European Prospective Investigation into Cancer and Nutrition-Potsdam) was used. Sixty-three SNPs in 32 genes were initially analyzed. Total intake of fat and fatty acid intake were calculated from validated baseline FFQ. The SNP × nutrient interaction was tested in multivariate adjusted regression models. The initial screening step revealed evidence that, for 4 SNPs (CAV2 rs2270188, DBI rs2084202, PPARG rs1801282, and SREBF1 rs2297508), disease susceptibility might depend on the amount and quality of fat intake. The insulin receptor regulator CAV2 rs2270188 G > T SNP was found to interact with dietary fat in the confirmatory case-cohort study. Using pooled data, homozygous individuals of the rare T-allele showed a 100% greater risk of type 2 diabetes if daily fat intake was increased from 30 to 40 % energy. An increase in dietary SFA from 10 to 20 % energy predicted an ~200% greater risk of type 2 diabetes. We found preliminary evidence that CAV2 rs2270188 interacts with dietary fat to affect risk of type 2 diabetes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1541-6100
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
141
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
177-81
pubmed:meshHeading
pubmed-meshheading:21178094-Adult, pubmed-meshheading:21178094-Alleles, pubmed-meshheading:21178094-Case-Control Studies, pubmed-meshheading:21178094-Caveolin 2, pubmed-meshheading:21178094-Diabetes Mellitus, Type 2, pubmed-meshheading:21178094-Dietary Fats, pubmed-meshheading:21178094-Female, pubmed-meshheading:21178094-Genetic Predisposition to Disease, pubmed-meshheading:21178094-Humans, pubmed-meshheading:21178094-Male, pubmed-meshheading:21178094-Middle Aged, pubmed-meshheading:21178094-Multivariate Analysis, pubmed-meshheading:21178094-Nutrigenomics, pubmed-meshheading:21178094-Nutritional Physiological Phenomena, pubmed-meshheading:21178094-PPAR gamma, pubmed-meshheading:21178094-Polymorphism, Single Nucleotide, pubmed-meshheading:21178094-Prospective Studies, pubmed-meshheading:21178094-Questionnaires, pubmed-meshheading:21178094-Risk Factors, pubmed-meshheading:21178094-Sterol Regulatory Element Binding Protein 1
pubmed:year
2011
pubmed:articleTitle
A two-step association study identifies CAV2 rs2270188 single nucleotide polymorphism interaction with fat intake in type 2 diabetes risk.
pubmed:affiliation
Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't