Source:http://linkedlifedata.com/resource/pubmed/id/21178094
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2011-1-21
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pubmed:abstractText |
Multiple genetic and environmental factors underlie the etiology of type 2 diabetes. To evaluate the influence of the relationship between dietary fat intake and single nucleotide polymorphisms (SNPs) in genes involved in fat assimilation on disease susceptibility, a 2-step approach using an exploratory case-control study (n = 192/384) and an independent, confirmatory case-cohort study (n = 614/2248) taken from the same prospective study population (European Prospective Investigation into Cancer and Nutrition-Potsdam) was used. Sixty-three SNPs in 32 genes were initially analyzed. Total intake of fat and fatty acid intake were calculated from validated baseline FFQ. The SNP × nutrient interaction was tested in multivariate adjusted regression models. The initial screening step revealed evidence that, for 4 SNPs (CAV2 rs2270188, DBI rs2084202, PPARG rs1801282, and SREBF1 rs2297508), disease susceptibility might depend on the amount and quality of fat intake. The insulin receptor regulator CAV2 rs2270188 G > T SNP was found to interact with dietary fat in the confirmatory case-cohort study. Using pooled data, homozygous individuals of the rare T-allele showed a 100% greater risk of type 2 diabetes if daily fat intake was increased from 30 to 40 % energy. An increase in dietary SFA from 10 to 20 % energy predicted an ~200% greater risk of type 2 diabetes. We found preliminary evidence that CAV2 rs2270188 interacts with dietary fat to affect risk of type 2 diabetes.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Caveolin 2,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats,
http://linkedlifedata.com/resource/pubmed/chemical/PPAR gamma,
http://linkedlifedata.com/resource/pubmed/chemical/SREBF1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Sterol Regulatory Element Binding...
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1541-6100
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
141
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
177-81
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pubmed:meshHeading |
pubmed-meshheading:21178094-Adult,
pubmed-meshheading:21178094-Alleles,
pubmed-meshheading:21178094-Case-Control Studies,
pubmed-meshheading:21178094-Caveolin 2,
pubmed-meshheading:21178094-Diabetes Mellitus, Type 2,
pubmed-meshheading:21178094-Dietary Fats,
pubmed-meshheading:21178094-Female,
pubmed-meshheading:21178094-Genetic Predisposition to Disease,
pubmed-meshheading:21178094-Humans,
pubmed-meshheading:21178094-Male,
pubmed-meshheading:21178094-Middle Aged,
pubmed-meshheading:21178094-Multivariate Analysis,
pubmed-meshheading:21178094-Nutrigenomics,
pubmed-meshheading:21178094-Nutritional Physiological Phenomena,
pubmed-meshheading:21178094-PPAR gamma,
pubmed-meshheading:21178094-Polymorphism, Single Nucleotide,
pubmed-meshheading:21178094-Prospective Studies,
pubmed-meshheading:21178094-Questionnaires,
pubmed-meshheading:21178094-Risk Factors,
pubmed-meshheading:21178094-Sterol Regulatory Element Binding Protein 1
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pubmed:year |
2011
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pubmed:articleTitle |
A two-step association study identifies CAV2 rs2270188 single nucleotide polymorphism interaction with fat intake in type 2 diabetes risk.
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pubmed:affiliation |
Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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