| pubmed-article:21177805 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21177805 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:21177805 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:21177805 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:21177805 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:21177805 | lifeskim:mentions | umls-concept:C0805527 | lld:lifeskim |
| pubmed-article:21177805 | lifeskim:mentions | umls-concept:C2003903 | lld:lifeskim |
| pubmed-article:21177805 | lifeskim:mentions | umls-concept:C0180112 | lld:lifeskim |
| pubmed-article:21177805 | lifeskim:mentions | umls-concept:C1515021 | lld:lifeskim |
| pubmed-article:21177805 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:21177805 | pubmed:dateCreated | 2011-2-18 | lld:pubmed |
| pubmed-article:21177805 | pubmed:abstractText | Human immunodeficiency virus type 1 (HIV-1) elite controllers maintain undetectable levels of viral replication in the absence of antiretroviral therapy (ART), but their underlying immunological and virological characteristics may vary. Here, we used a whole-genome transcriptional profiling approach to characterize gene expression signatures of CD4 T cells from an unselected cohort of elite controllers. The transcriptional profiles for the majority of elite controllers were similar to those of ART-treated patients but different from those of HIV-1-negative persons. Yet, a smaller proportion of elite controllers showed an alternative gene expression pattern that was indistinguishable from that of HIV-1-negative persons but different from that of highly active antiretroviral therapy (HAART)-treated individuals. Elite controllers with the latter gene expression signature had significantly higher CD4 T cell counts and lower levels of HIV-1-specific CD8(+) T cell responses but did not significantly differ from other elite controllers in terms of HLA class I alleles, HIV-1 viral loads determined by ultrasensitive single-copy PCR assays, or chemokine receptor polymorphisms. Thus, these data identify a specific subgroup of elite controllers whose immunological and gene expression characteristics approximate those of HIV-1-negative persons. | lld:pubmed |
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| pubmed-article:21177805 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21177805 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21177805 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21177805 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21177805 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21177805 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21177805 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21177805 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21177805 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21177805 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21177805 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21177805 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21177805 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21177805 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21177805 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21177805 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:21177805 | pubmed:issn | 1098-5514 | lld:pubmed |
| pubmed-article:21177805 | pubmed:author | pubmed-author:EschJ FJF | lld:pubmed |
| pubmed-article:21177805 | pubmed:author | pubmed-author:TelentiAmalio... | lld:pubmed |
| pubmed-article:21177805 | pubmed:author | pubmed-author:Martinez-Pica... | lld:pubmed |
| pubmed-article:21177805 | pubmed:author | pubmed-author:LichterfeldMa... | lld:pubmed |
| pubmed-article:21177805 | pubmed:author | pubmed-author:YuXu GXG | lld:pubmed |
| pubmed-article:21177805 | pubmed:author | pubmed-author:RosenbergEric... | lld:pubmed |
| pubmed-article:21177805 | pubmed:author | pubmed-author:ChurchGeorgeG | lld:pubmed |
| pubmed-article:21177805 | pubmed:author | pubmed-author:PereyraFloren... | lld:pubmed |
| pubmed-article:21177805 | pubmed:author | pubmed-author:CrosbySeth... | lld:pubmed |
| pubmed-article:21177805 | pubmed:author | pubmed-author:VigneaultFran... | lld:pubmed |
| pubmed-article:21177805 | pubmed:author | pubmed-author:WoodsMatthewM | lld:pubmed |
| pubmed-article:21177805 | pubmed:author | pubmed-author:BuzonMaria... | lld:pubmed |
| pubmed-article:21177805 | pubmed:author | pubmed-author:RychertJennif... | lld:pubmed |
| pubmed-article:21177805 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21177805 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:21177805 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21177805 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21177805 | pubmed:pagination | 3015-9 | lld:pubmed |
| pubmed-article:21177805 | pubmed:dateRevised | 2011-9-13 | lld:pubmed |
| pubmed-article:21177805 | pubmed:meshHeading | pubmed-meshheading:21177805... | lld:pubmed |
| pubmed-article:21177805 | pubmed:meshHeading | pubmed-meshheading:21177805... | lld:pubmed |
| pubmed-article:21177805 | pubmed:meshHeading | pubmed-meshheading:21177805... | lld:pubmed |
| pubmed-article:21177805 | pubmed:meshHeading | pubmed-meshheading:21177805... | lld:pubmed |
| pubmed-article:21177805 | pubmed:meshHeading | pubmed-meshheading:21177805... | lld:pubmed |
| pubmed-article:21177805 | pubmed:meshHeading | pubmed-meshheading:21177805... | lld:pubmed |
| pubmed-article:21177805 | pubmed:meshHeading | pubmed-meshheading:21177805... | lld:pubmed |
| pubmed-article:21177805 | pubmed:meshHeading | pubmed-meshheading:21177805... | lld:pubmed |
| pubmed-article:21177805 | pubmed:meshHeading | pubmed-meshheading:21177805... | lld:pubmed |
| pubmed-article:21177805 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21177805 | pubmed:articleTitle | Transcriptional profiling of CD4 T cells identifies distinct subgroups of HIV-1 elite controllers. | lld:pubmed |
| pubmed-article:21177805 | pubmed:affiliation | Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA. | lld:pubmed |
| pubmed-article:21177805 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21177805 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21177805 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
