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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2011-2-18
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pubmed:abstractText |
Human immunodeficiency virus type 1 (HIV-1) elite controllers maintain undetectable levels of viral replication in the absence of antiretroviral therapy (ART), but their underlying immunological and virological characteristics may vary. Here, we used a whole-genome transcriptional profiling approach to characterize gene expression signatures of CD4 T cells from an unselected cohort of elite controllers. The transcriptional profiles for the majority of elite controllers were similar to those of ART-treated patients but different from those of HIV-1-negative persons. Yet, a smaller proportion of elite controllers showed an alternative gene expression pattern that was indistinguishable from that of HIV-1-negative persons but different from that of highly active antiretroviral therapy (HAART)-treated individuals. Elite controllers with the latter gene expression signature had significantly higher CD4 T cell counts and lower levels of HIV-1-specific CD8(+) T cell responses but did not significantly differ from other elite controllers in terms of HLA class I alleles, HIV-1 viral loads determined by ultrasensitive single-copy PCR assays, or chemokine receptor polymorphisms. Thus, these data identify a specific subgroup of elite controllers whose immunological and gene expression characteristics approximate those of HIV-1-negative persons.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21177805-10607709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21177805-12368910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21177805-12808457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21177805-15381726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21177805-16199517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21177805-17041633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21177805-17151109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21177805-17428922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21177805-17457100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21177805-17641165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21177805-17981085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21177805-18025130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21177805-18171295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21177805-18187620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21177805-18332425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21177805-19062316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21177805-19063693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21177805-19265012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21177805-19390417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21177805-19656066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21177805-19880382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21177805-19923174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21177805-20195503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21177805-20350494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21177805-20616270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21177805-20652514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21177805-8597949
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1098-5514
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pubmed:author |
pubmed-author:BuzonMaria JMJ,
pubmed-author:ChurchGeorgeG,
pubmed-author:CrosbySeth DSD,
pubmed-author:EschJ FJF,
pubmed-author:LichterfeldMathiasM,
pubmed-author:Martinez-PicadoJavierJ,
pubmed-author:PereyraFlorenciaF,
pubmed-author:RosenbergEric SES,
pubmed-author:RychertJenniferJ,
pubmed-author:TelentiAmalioA,
pubmed-author:VigneaultFrancoisF,
pubmed-author:WoodsMatthewM,
pubmed-author:YuXu GXG
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pubmed:issnType |
Electronic
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3015-9
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pubmed:dateRevised |
2011-9-13
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pubmed:meshHeading |
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pubmed:year |
2011
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pubmed:articleTitle |
Transcriptional profiling of CD4 T cells identifies distinct subgroups of HIV-1 elite controllers.
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pubmed:affiliation |
Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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