| pubmed-article:21175595 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21175595 | lifeskim:mentions | umls-concept:C0021289 | lld:lifeskim |
| pubmed-article:21175595 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:21175595 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:21175595 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:21175595 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:21175595 | lifeskim:mentions | umls-concept:C1334114 | lld:lifeskim |
| pubmed-article:21175595 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:21175595 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:21175595 | lifeskim:mentions | umls-concept:C0948201 | lld:lifeskim |
| pubmed-article:21175595 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:21175595 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:21175595 | pubmed:dateCreated | 2011-2-9 | lld:pubmed |
| pubmed-article:21175595 | pubmed:abstractText | Transplantation tolerance induced by neonatal injection of semi-allogeneic spleen cells is associated with a pathological syndrome caused by T helper type 2 (Th2) differentiation of donor-specific CD4(+) T lymphocytes. We have shown previously that this Th2-biased response is inhibited by host CD8(+) T cells. Herein, we demonstrate that upon neonatal immunization with (A/J × BALB/c)F(1) spleen cells, BALB/c mice expand a population of CD8(+) T cells expressing both CD25 and forkhead box P3 (FoxP3) markers. In this setting, CD8(+) CD25(+) T cells predominantly produce interferon (IFN)-? and interleukin (IL)-10 and are efficient in controlling IL-4, IL-5 and IL-13 production by donor-specific CD4(+) T cells in vitro. CD8(+) FoxP3(-) T cells are single producers of IFN-? or IL-10, whereas CD8(+) FoxP3(+) T cells are double producers of IFN-? and IL-10. We further demonstrate that IFN-? and IL-10 are two major cytokines produced by CD8(+) T cells involved in the in vivo regulation of Th2-type pathology. In this setting, we conclude that neonatal alloimmunization induces the expansion of several regulatory CD8(+) T cells which may control Th2 activities via IFN-? and IL-10. | lld:pubmed |
| pubmed-article:21175595 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21175595 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21175595 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21175595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21175595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21175595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21175595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21175595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21175595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21175595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21175595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21175595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21175595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21175595 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21175595 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:21175595 | pubmed:issn | 1365-2249 | lld:pubmed |
| pubmed-article:21175595 | pubmed:author | pubmed-author:AdamsBB | lld:pubmed |
| pubmed-article:21175595 | pubmed:author | pubmed-author:DuboisAA | lld:pubmed |
| pubmed-article:21175595 | pubmed:author | pubmed-author:GoldmanMM | lld:pubmed |
| pubmed-article:21175595 | pubmed:author | pubmed-author:FlamantFF | lld:pubmed |
| pubmed-article:21175595 | pubmed:author | pubmed-author:LhomméFF | lld:pubmed |
| pubmed-article:21175595 | pubmed:author | pubmed-author:DelbauveSS | lld:pubmed |
| pubmed-article:21175595 | pubmed:author | pubmed-author:DebockII | lld:pubmed |
| pubmed-article:21175595 | pubmed:copyrightInfo | © 2010 The Authors. Clinical and Experimental Immunology © 2010 British Society for Immunology. | lld:pubmed |
| pubmed-article:21175595 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21175595 | pubmed:volume | 163 | lld:pubmed |
| pubmed-article:21175595 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21175595 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21175595 | pubmed:pagination | 354-61 | lld:pubmed |
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| pubmed-article:21175595 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21175595 | pubmed:articleTitle | Expansion of regulatory CD8+ CD25+ T cells after neonatal alloimmunization. | lld:pubmed |
| pubmed-article:21175595 | pubmed:affiliation | Institut d'Immunologie Médicale, Université Libre de Bruxelles, Gosselies, Belgium. | lld:pubmed |
| pubmed-article:21175595 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21175595 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
