|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2011-2-9
|
|
pubmed:abstractText |
Transplantation tolerance induced by neonatal injection of semi-allogeneic spleen cells is associated with a pathological syndrome caused by T helper type 2 (Th2) differentiation of donor-specific CD4(+) T lymphocytes. We have shown previously that this Th2-biased response is inhibited by host CD8(+) T cells. Herein, we demonstrate that upon neonatal immunization with (A/J × BALB/c)F(1) spleen cells, BALB/c mice expand a population of CD8(+) T cells expressing both CD25 and forkhead box P3 (FoxP3) markers. In this setting, CD8(+) CD25(+) T cells predominantly produce interferon (IFN)-? and interleukin (IL)-10 and are efficient in controlling IL-4, IL-5 and IL-13 production by donor-specific CD4(+) T cells in vitro. CD8(+) FoxP3(-) T cells are single producers of IFN-? or IL-10, whereas CD8(+) FoxP3(+) T cells are double producers of IFN-? and IL-10. We further demonstrate that IFN-? and IL-10 are two major cytokines produced by CD8(+) T cells involved in the in vivo regulation of Th2-type pathology. In this setting, we conclude that neonatal alloimmunization induces the expansion of several regulatory CD8(+) T cells which may control Th2 activities via IFN-? and IL-10.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Foxp3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/IL10 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Il2ra protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin E,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2 Receptor alpha Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/beta 2-Microglobulin
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
1365-2249
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
© 2010 The Authors. Clinical and Experimental Immunology © 2010 British Society for Immunology.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
163
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
354-61
|
|
pubmed:meshHeading |
pubmed-meshheading:21175595-Animals,
pubmed-meshheading:21175595-Animals, Newborn,
pubmed-meshheading:21175595-Antigens, CD,
pubmed-meshheading:21175595-CD8-Positive T-Lymphocytes,
pubmed-meshheading:21175595-Forkhead Transcription Factors,
pubmed-meshheading:21175595-Gene Expression,
pubmed-meshheading:21175595-Immune Tolerance,
pubmed-meshheading:21175595-Immunization,
pubmed-meshheading:21175595-Immunoglobulin E,
pubmed-meshheading:21175595-Interferon-gamma,
pubmed-meshheading:21175595-Interleukin-10,
pubmed-meshheading:21175595-Interleukin-2 Receptor alpha Subunit,
pubmed-meshheading:21175595-Lymph Nodes,
pubmed-meshheading:21175595-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:21175595-Mice,
pubmed-meshheading:21175595-Mice, Inbred A,
pubmed-meshheading:21175595-Mice, Inbred BALB C,
pubmed-meshheading:21175595-Mice, Inbred C57BL,
pubmed-meshheading:21175595-Mice, Knockout,
pubmed-meshheading:21175595-Spleen,
pubmed-meshheading:21175595-Splenomegaly,
pubmed-meshheading:21175595-T-Lymphocyte Subsets,
pubmed-meshheading:21175595-T-Lymphocytes,
pubmed-meshheading:21175595-Th2 Cells,
pubmed-meshheading:21175595-Transplantation, Homologous,
pubmed-meshheading:21175595-Transplantation Tolerance,
pubmed-meshheading:21175595-beta 2-Microglobulin
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
Expansion of regulatory CD8+ CD25+ T cells after neonatal alloimmunization.
|
|
pubmed:affiliation |
Institut d'Immunologie Médicale, Université Libre de Bruxelles, Gosselies, Belgium.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
