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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2011-2-17
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pubmed:abstractText |
Amplification and activating mutations of the epidermal growth factor receptor (EGFR) oncogene are molecular hallmarks of glioblastomas. We hypothesized that deletion of NFKBIA (encoding nuclear factor of ?-light polypeptide gene enhancer in B-cells inhibitor-?), an inhibitor of the EGFR-signaling pathway, promotes tumorigenesis in glioblastomas that do not have alterations of EGFR.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1533-4406
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pubmed:author |
pubmed-author:AldapeKenneth DKD,
pubmed-author:AlvarezAngel AAA,
pubmed-author:BredelClaudiaC,
pubmed-author:BredelMarkusM,
pubmed-author:CarroMaria SMS,
pubmed-author:ChakravartiArnabA,
pubmed-author:ChandlerJames PJP,
pubmed-author:DaiFangpingF,
pubmed-author:DubnerStevenS,
pubmed-author:FerrareseRobertoR,
pubmed-author:HarshGriffith RGR4th,
pubmed-author:HeXiaolinX,
pubmed-author:LukacPaul JPJ,
pubmed-author:MobleyBretB,
pubmed-author:PhillipsHeidi SHS,
pubmed-author:RenfrowJaclyn JJJ,
pubmed-author:RobePierre APA,
pubmed-author:ScheckAdrienne CAC,
pubmed-author:ScholtensDenise MDM,
pubmed-author:SikicBranimir IBI,
pubmed-author:TaggeMichael JMJ,
pubmed-author:VogelHannesH,
pubmed-author:WeyerbrockAstridA,
pubmed-author:YadavAjay KAK,
pubmed-author:YuIrene L YIL
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pubmed:issnType |
Electronic
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pubmed:day |
17
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pubmed:volume |
364
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
627-37
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pubmed:dateRevised |
2011-7-21
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pubmed:meshHeading |
pubmed-meshheading:21175304-DNA Mutational Analysis,
pubmed-meshheading:21175304-Gene Amplification,
pubmed-meshheading:21175304-Gene Deletion,
pubmed-meshheading:21175304-Gene Expression,
pubmed-meshheading:21175304-Genes, erbB-1,
pubmed-meshheading:21175304-Glioblastoma,
pubmed-meshheading:21175304-Humans,
pubmed-meshheading:21175304-I-kappa B Proteins,
pubmed-meshheading:21175304-Kaplan-Meier Estimate,
pubmed-meshheading:21175304-Prognosis,
pubmed-meshheading:21175304-Tumor Cells, Cultured
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pubmed:year |
2011
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pubmed:articleTitle |
NFKBIA deletion in glioblastomas.
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pubmed:affiliation |
Department of Neurosurgery, Neurocenter, University of Freiburg, Freiburg, Germany. markus.bredel@uniklinik-freiburg.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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