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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2011-5-17
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pubmed:abstractText |
Tamoxifen (TAM) is a nonsteroidal antiestrogen that has been widely used in the treatment of breast cancer through its anti-estrogen activity. Recent studies show that TAM is cytotoxic to both estrogen receptor (ER)-positive and ER-negative cells via the induction of apoptosis. However, the molecular mechanisms of this effect are not well understood. In the present study, we investigated the roles of c-Src, ERK, AKT and c-Cbl ubiquitin ligases during TAM-induced apoptosis of MCF-7 cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1651-226X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
693-9
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pubmed:meshHeading |
pubmed-meshheading:21175263-Apoptosis,
pubmed-meshheading:21175263-Breast Neoplasms,
pubmed-meshheading:21175263-Carcinoma,
pubmed-meshheading:21175263-Cell Line, Tumor,
pubmed-meshheading:21175263-Cell Survival,
pubmed-meshheading:21175263-Down-Regulation,
pubmed-meshheading:21175263-Drug Resistance, Neoplasm,
pubmed-meshheading:21175263-Estrogen Antagonists,
pubmed-meshheading:21175263-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:21175263-Female,
pubmed-meshheading:21175263-Humans,
pubmed-meshheading:21175263-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:21175263-Proto-Oncogene Proteins c-cbl,
pubmed-meshheading:21175263-Signal Transduction,
pubmed-meshheading:21175263-Tamoxifen,
pubmed-meshheading:21175263-Ubiquitin-Protein Ligases
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pubmed:year |
2011
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pubmed:articleTitle |
Ubiquitin ligase c-Cbl is involved in tamoxifen-induced apoptosis of MCF-7 cells by downregulating the survival signals.
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pubmed:affiliation |
Department of Medical Oncology, The First Hospital, China Medical University, Heping District, Shenyang, Liaoning Province, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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