Source:http://linkedlifedata.com/resource/pubmed/id/21175248
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2010-12-23
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pubmed:abstractText |
Herpes simplex virus type 2 (HSV-2) infection is the most common cause of genital ulcerative disease in the developed world. Keratinocytes are the primary cells involved in clinical lesions caused by HSV-2. In our study, we intensively examined cytokine expression in the HSV-2-infected keratinocytes. We observed upregulation of a series of cytokines including early-induced antiviral cytokines as interferons ?, ? (IFN-?, ?), tumor necrosis factor ? (TNF-?), colony stimulating factors (CSFs) as G-CSF, GM-CSF, interleukin 3 (IL-3), growth factors (EGF, KGF, and IGF-?1), defensins, selectins, leukocyte function-associated antigens (LFAs,) and toll-like receptors (TLR-2, 3, 4, and 9). More importantly, we found that HSV-2-infected keratinocytes stimulated the proliferation of lymphocytes in co-cultivation system. These data suggest that keratinocytes participate in the immune response to HSV-2 infection in two ways. They secrete inflammatory cytokines to resist the HSV-2 infection directly and recruit the immune cells to eliminate the primary infection indirectly and enhance the adaptive immunity to prevent subsequent infections.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0001-723X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
261-7
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pubmed:meshHeading |
pubmed-meshheading:21175248-Animals,
pubmed-meshheading:21175248-Cell Line,
pubmed-meshheading:21175248-Cercopithecus aethiops,
pubmed-meshheading:21175248-Cytokines,
pubmed-meshheading:21175248-Herpes Simplex,
pubmed-meshheading:21175248-Herpesvirus 2, Human,
pubmed-meshheading:21175248-Humans,
pubmed-meshheading:21175248-Keratinocytes,
pubmed-meshheading:21175248-Up-Regulation,
pubmed-meshheading:21175248-Vero Cells
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pubmed:year |
2010
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pubmed:articleTitle |
Keratinocytes play a role in the immunity to Herpes simplex virus type 2 infection.
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pubmed:affiliation |
Shenzhen Key Lab for Translational Medicine of Dermatology, Guangdong Province, People's Republic of China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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