|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0023688,
umls-concept:C0030001,
umls-concept:C0036849,
umls-concept:C0205460,
umls-concept:C0441655,
umls-concept:C1442518,
umls-concept:C1522290,
umls-concept:C1552652,
umls-concept:C1552685,
umls-concept:C1705195,
umls-concept:C2603343
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|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2011-2-17
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|
pubmed:abstractText |
A series of enantiomerically pure benzopyrano[3,4-b][1,4]oxazines have been synthesised and tested for their ability to inhibit P-glycoprotein. Reducing the conformational flexibility of the molecules leads to remarkable differences in the activity of diastereoisomers. Docking studies into a homology model of human P-gp provide first insights into potential binding areas for these compounds.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
1364-548X
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
7
|
|
pubmed:volume |
47
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2586-8
|
|
pubmed:meshHeading |
|
|
pubmed:year |
2011
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|
pubmed:articleTitle |
Probing the stereoselectivity of P-glycoprotein-synthesis, biological activity and ligand docking studies of a set of enantiopure benzopyrano[3,4-b][1,4]oxazines.
|
|
pubmed:affiliation |
Department of Medicinal Chemistry, University of Vienna, Vienna, Austria.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
