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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2011-3-10
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pubmed:abstractText |
Autophagy has recently elicited significant attention as a mechanism that either protects or promotes cell death, although different autophagy pathways, and the cellular context in which they occur, remain to be elucidated. We report a thorough cellular and biochemical characterization of a novel selective autophagy that works as a protective cell response. This new selective autophagy is activated in pancreatic acinar cells during pancreatitis-induced vesicular transport alteration to sequester and degrade potentially deleterious activated zymogen granules. We have coined the term "zymophagy" to refer to this process. The autophagy-related protein VMP1, the ubiquitin-protease USP9x, and the ubiquitin-binding protein p62 mediate zymophagy. Moreover, VMP1 interacts with USP9x, indicating that there is a close cooperation between the autophagy pathway and the ubiquitin recognition machinery required for selective autophagosome formation. Zymophagy is activated by experimental pancreatitis in genetically engineered mice and cultured pancreatic acinar cells and by acute pancreatitis in humans. Furthermore, zymophagy has pathophysiological relevance by controlling pancreatitis-induced intracellular zymogen activation and helping to prevent cell death. Together, these data reveal a novel selective form of autophagy mediated by the VMP1-USP9x-p62 pathway, as a cellular protective response.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/Heat-Shock Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SQSTM1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Sqstm1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/USP9X protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin Thiolesterase,
http://linkedlifedata.com/resource/pubmed/chemical/Usp9x protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/VMP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/VMP1 protein, rat
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1083-351X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
11
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pubmed:volume |
286
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8308-24
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pubmed:dateRevised |
2011-6-9
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pubmed:meshHeading |
pubmed-meshheading:21173155-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:21173155-Animals,
pubmed-meshheading:21173155-Autophagy,
pubmed-meshheading:21173155-Cell Line, Tumor,
pubmed-meshheading:21173155-Endopeptidases,
pubmed-meshheading:21173155-Enzyme Activation,
pubmed-meshheading:21173155-Enzyme Precursors,
pubmed-meshheading:21173155-Heat-Shock Proteins,
pubmed-meshheading:21173155-Humans,
pubmed-meshheading:21173155-Membrane Proteins,
pubmed-meshheading:21173155-Mice,
pubmed-meshheading:21173155-Mice, Transgenic,
pubmed-meshheading:21173155-Pancreas, Exocrine,
pubmed-meshheading:21173155-Pancreatitis, Acute Necrotizing,
pubmed-meshheading:21173155-Rats,
pubmed-meshheading:21173155-Ubiquitin Thiolesterase
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pubmed:year |
2011
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pubmed:articleTitle |
Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death.
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pubmed:affiliation |
Department of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires, C1113AAD Buenos Aires, Argentina.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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