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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-2-1
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pubmed:abstractText |
We tested the hypothesis that levels of pentraxin high sensitivity C-reactive protein and pentraxin 3 might be correlated with cardiovascular complications in patients with essential thrombocythemia and polycythemia vera. High sensitivity C-reactive protein and pentraxin 3 were measured in 244 consecutive essential thrombocythemia and polycythemia vera patients in whom, after a median follow up of 5.3 years (range 0-24), 68 cardiovascular events were diagnosed. The highest C-reactive protein tertile was compared with the lowest (>3 vs. <1 mg/L) and correlated with age (P=0.001), phenotype (polycythemia vera vs. essential thrombocythemia, P=0.006), cardiovascular risk factors (P=0.012) and JAK2V617F allele burden greater than 50% (P=0.003). Major thrombosis rate was higher in the highest C-reactive protein tertile (P=0.01) and lower at the highest pentraxin 3 levels (P=0.045). These associations remained significant in multivariate analyses and indicate that blood levels of high sensitivity C-reactive protein and petraxin 3 independently and in opposite ways modulate the intrinsic risk of cardiovascular events in patients with myeloproliferative disorders.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173097-12829015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173097-15477419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173097-15710945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173097-16081684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173097-16115126,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/21173097-18268142,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/21173097-19166684,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/21173097-19713225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173097-20031199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173097-20031200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173097-20208538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173097-21282719
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1592-8721
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pubmed:author |
pubmed-author:AGIMM and IIC Investigators,
pubmed-author:AntonioliElisabettaE,
pubmed-author:BarbuiTizianoT,
pubmed-author:BarosiGiovanniG,
pubmed-author:BottazziBarbaraB,
pubmed-author:CarobbioAlessandraA,
pubmed-author:CuccovilloIvanI,
pubmed-author:FinazziGuidoG,
pubmed-author:GuglielmelliPaolaP,
pubmed-author:MantovaniAlbertoA,
pubmed-author:MarchioliRobertoR,
pubmed-author:OttomanoCosimoC,
pubmed-author:PancrazziAlessandroA,
pubmed-author:RambaldiAlessandroA,
pubmed-author:SalmoiraghiSilviaS,
pubmed-author:VannucchiAlessandro MAM,
pubmed-author:ZilioPioP
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pubmed:issnType |
Electronic
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pubmed:volume |
96
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
315-8
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pubmed:meshHeading |
pubmed-meshheading:21173097-Adult,
pubmed-meshheading:21173097-Aged,
pubmed-meshheading:21173097-Aged, 80 and over,
pubmed-meshheading:21173097-C-Reactive Protein,
pubmed-meshheading:21173097-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:21173097-Female,
pubmed-meshheading:21173097-Follow-Up Studies,
pubmed-meshheading:21173097-Humans,
pubmed-meshheading:21173097-Inflammation,
pubmed-meshheading:21173097-Janus Kinase 2,
pubmed-meshheading:21173097-Male,
pubmed-meshheading:21173097-Middle Aged,
pubmed-meshheading:21173097-Mutation,
pubmed-meshheading:21173097-Polycythemia Vera,
pubmed-meshheading:21173097-Prognosis,
pubmed-meshheading:21173097-Risk Factors,
pubmed-meshheading:21173097-Serum Amyloid P-Component,
pubmed-meshheading:21173097-Survival Rate,
pubmed-meshheading:21173097-Thrombocythemia, Essential,
pubmed-meshheading:21173097-Thrombosis,
pubmed-meshheading:21173097-Young Adult
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pubmed:year |
2011
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pubmed:articleTitle |
Inflammation and thrombosis in essential thrombocythemia and polycythemia vera: different role of C-reactive protein and pentraxin 3.
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pubmed:affiliation |
Hematology Department, Ospedali Riuniti, Largo Barozzi 1, 24128 Bergamo, Italy. tbarbui@ospedaliriuniti.bergamo.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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