Source:http://linkedlifedata.com/resource/pubmed/id/21172937
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2011-2-24
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| pubmed:abstractText |
Our goal was to determine the role of vascular endothelial growth factor (VEGF) in diagnosing of pleural effusion (PE) in order to select patients deserving of more aggressive procedures. Seventy-nine consecutive patients with undiagnosed unilateral PE were enrolled. Pleural VEGF levels, measured using enzyme-linked immunosorbent assay (ELISA), were correlated to etiology of PEs and other markers (protein, lactic dehydrogenase, amylase, glucose). The median level of VEGF in exudates (n=65) was significantly higher than that in transudates (P=0.0001) and among exudates, it was significantly higher in malignant (n=49) than that in benign exudates (P=0.005). No significant differences were observed between malignant effusions due to lung cancer (n=11) and other malignant effusions [mesothelioma (n=13) and/or extra-thoracic cancer]. Among all variables evaluated, logistic regression found that only VEGF was significantly correlated with the presence of malignant disease (P=0.002). Analysis of the receiver operating characterists (ROC) curves showed that the areas under the curve of VEGF were significantly larger than that of amylase (P=0.02), glucose (P=0.01), lactic dehydrogenase (P=0.001) and protein (P=0.01). VEGF increased the diagnostic rate of cytological examination by 24%. VEGF may represent a helpful adjunct to conventional diagnostic tools in ruling out malignancy as a probable diagnosis, thus guiding the selection of patients who might benefit from further invasive procedures.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amylases,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/L-Lactate Dehydrogenase,
http://linkedlifedata.com/resource/pubmed/chemical/VEGFA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
1569-9285
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
12
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
420-4
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| pubmed:meshHeading |
pubmed-meshheading:21172937-Adult,
pubmed-meshheading:21172937-Aged,
pubmed-meshheading:21172937-Aged, 80 and over,
pubmed-meshheading:21172937-Amylases,
pubmed-meshheading:21172937-Biological Markers,
pubmed-meshheading:21172937-Diagnosis, Differential,
pubmed-meshheading:21172937-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:21172937-Female,
pubmed-meshheading:21172937-Glucose,
pubmed-meshheading:21172937-Humans,
pubmed-meshheading:21172937-Italy,
pubmed-meshheading:21172937-L-Lactate Dehydrogenase,
pubmed-meshheading:21172937-Logistic Models,
pubmed-meshheading:21172937-Male,
pubmed-meshheading:21172937-Middle Aged,
pubmed-meshheading:21172937-Odds Ratio,
pubmed-meshheading:21172937-Paracentesis,
pubmed-meshheading:21172937-Pleural Effusion,
pubmed-meshheading:21172937-Pleural Effusion, Malignant,
pubmed-meshheading:21172937-Predictive Value of Tests,
pubmed-meshheading:21172937-Prognosis,
pubmed-meshheading:21172937-ROC Curve,
pubmed-meshheading:21172937-Risk Assessment,
pubmed-meshheading:21172937-Risk Factors,
pubmed-meshheading:21172937-Vascular Endothelial Growth Factor A,
pubmed-meshheading:21172937-Young Adult
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| pubmed:year |
2011
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| pubmed:articleTitle |
Vascular endothelial growth factor in pleural fluid for differential diagnosis of benign and malignant origin and its clinical applications.
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| pubmed:affiliation |
Thoracic Surgery Unit, Second University of Naples, Naples, Italy.
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| pubmed:publicationType |
Journal Article,
Evaluation Studies
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