Source:http://linkedlifedata.com/resource/pubmed/id/21172866
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2011-1-6
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| pubmed:abstractText |
Interaction between the nervous and immune systems greatly contributes to inflammatory disease. In organs at the interface between our body and the environment, the sensory neuropeptide substance P (SP) is one key mediator of an acute local stress response through neurogenic inflammation but may also alter cytokine balance and dendritic cell (DC) function. Using a combined murine allergic inflammation/noise stress model with C57BL/6 mice, we show in this paper that SP--released during repeated stress exposure--has the capacity to markedly attenuate inflammation. In particular, repeated stress exposure prior to allergen sensitization increases DC-nerve fiber contacts, enhances DC migration and maturation, alters cytokine balance, and increases levels of IL-2 and T regulatory cell numbers in local lymph nodes and inflamed tissue in a neurokinin 1-SP-receptor (neurokinin-1 receptor)-dependent manner. Concordantly, allergic inflammation is significantly reduced after repeated stress exposure. We conclude that SP/repeated stress prior to immune activation acts protolerogenically and thereby beneficially in inflammation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
1550-6606
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
186
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
848-55
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| pubmed:meshHeading |
pubmed-meshheading:21172866-Allergens,
pubmed-meshheading:21172866-Animals,
pubmed-meshheading:21172866-Antigen Presentation,
pubmed-meshheading:21172866-Cells, Cultured,
pubmed-meshheading:21172866-Coculture Techniques,
pubmed-meshheading:21172866-Dendritic Cells,
pubmed-meshheading:21172866-Dermatitis, Allergic Contact,
pubmed-meshheading:21172866-Disease Models, Animal,
pubmed-meshheading:21172866-Electric Stimulation,
pubmed-meshheading:21172866-Female,
pubmed-meshheading:21172866-Inflammation Mediators,
pubmed-meshheading:21172866-Langerhans Cells,
pubmed-meshheading:21172866-Mice,
pubmed-meshheading:21172866-Mice, Inbred C57BL,
pubmed-meshheading:21172866-Noise,
pubmed-meshheading:21172866-Ovalbumin,
pubmed-meshheading:21172866-Pilot Projects,
pubmed-meshheading:21172866-Random Allocation,
pubmed-meshheading:21172866-Stress, Physiological,
pubmed-meshheading:21172866-Substance P
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Substance P is a key mediator of stress-induced protection from allergic sensitization via modified antigen presentation.
|
| pubmed:affiliation |
University-Medicine Charité, Charité Center 12 for Internal Medicine and Dermatology, D-10117 Berlin, Germany.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|