Source:http://linkedlifedata.com/resource/pubmed/id/21172365
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2011-6-20
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| pubmed:abstractText |
Most neuropsychiatric disorders, including stress-related mood disorders, are complex multi-parametric syndromes. Diagnoses are therefore hard to establish and current therapeutic strategies suffer from significant variability in effectiveness, making the understanding of inter-individual variations crucial to unveiling effective new treatments. In rats, such individual differences are observed during exposure to a novel environment, where individuals will exhibit either high or low locomotor activity and can thus be separated into high (HR) and low (LR) responders, respectively. In rodents, a long-lasting, psychosocial, stress-induced depressive state can be triggered by exposure to a social defeat procedure. We therefore analyzed the respective vulnerabilities of HR and LR animals to long-lasting, social defeat-induced behavioral alterations relevant to mood disorders. Two weeks after four daily consecutive social defeat exposures, HR animals exhibit higher anxiety levels, reduced body weight gain, sucrose preference, and a marked social avoidance. LR animals, however, remain unaffected. Moreover, while repeated social defeat exposure induces long-lasting contextual fear memory in both HR and LR animals, only HR individuals exhibit marked freezing behavior four weeks after a single social defeat. Combined, these findings highlight the critical involvement of inter-individual variations in novelty-seeking behavior in the vulnerability to stress-related mood disorders, and uncover a promising model for posttraumatic stress disorder.
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| pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/R01 MH087583-01A1,
http://linkedlifedata.com/resource/pubmed/grant/R01 MH087583-02,
http://linkedlifedata.com/resource/pubmed/grant/R21 MH081046-0182,
http://linkedlifedata.com/resource/pubmed/grant/R21 MH081046-01A2,
http://linkedlifedata.com/resource/pubmed/grant/R21 MH083128-01A2
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
1873-507X
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2010 Elsevier Inc. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:day |
3
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| pubmed:volume |
104
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
296-305
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| pubmed:meshHeading |
pubmed-meshheading:21172365-Analysis of Variance,
pubmed-meshheading:21172365-Animals,
pubmed-meshheading:21172365-Avoidance Learning,
pubmed-meshheading:21172365-Conditioning, Classical,
pubmed-meshheading:21172365-Disease Models, Animal,
pubmed-meshheading:21172365-Dominance-Subordination,
pubmed-meshheading:21172365-Exploratory Behavior,
pubmed-meshheading:21172365-Fear,
pubmed-meshheading:21172365-Female,
pubmed-meshheading:21172365-Food Preferences,
pubmed-meshheading:21172365-Individuality,
pubmed-meshheading:21172365-Male,
pubmed-meshheading:21172365-Memory,
pubmed-meshheading:21172365-Motor Activity,
pubmed-meshheading:21172365-Orchiectomy,
pubmed-meshheading:21172365-Rats,
pubmed-meshheading:21172365-Rats, Long-Evans,
pubmed-meshheading:21172365-Rats, Sprague-Dawley,
pubmed-meshheading:21172365-Stress, Psychological,
pubmed-meshheading:21172365-Sucrose,
pubmed-meshheading:21172365-Time Factors
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| pubmed:year |
2011
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| pubmed:articleTitle |
Individual differences in novelty-seeking behavior in rats as a model for psychosocial stress-related mood disorders.
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| pubmed:affiliation |
Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL 32306, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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