|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
2010-12-20
|
|
pubmed:abstractText |
Celastrol is a natural proteasome inhibitor that exhibits promising anti-tumor effects in human malignancies, especially the androgen-independent prostate cancer (AIPC) with constitutive NF-?B activation. Celastrol induces apoptosis by means of proteasome inhibition and suppresses prostate tumor growth. However, the detailed mechanism of action remains elusive. In the current study, we aim to test the hypothesis that celastrol suppresses AIPC progression via inhibiting the constitutive NF-?B activity as well as modulating the Bcl-2 family proteins.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1932-6203
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
5
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
e14153
|
|
pubmed:meshHeading |
pubmed-meshheading:21170316-Androgens,
pubmed-meshheading:21170316-Animals,
pubmed-meshheading:21170316-Apoptosis,
pubmed-meshheading:21170316-Cell Line, Tumor,
pubmed-meshheading:21170316-Disease Progression,
pubmed-meshheading:21170316-Enzyme Inhibitors,
pubmed-meshheading:21170316-Female,
pubmed-meshheading:21170316-Humans,
pubmed-meshheading:21170316-Inhibitory Concentration 50,
pubmed-meshheading:21170316-Male,
pubmed-meshheading:21170316-Mice,
pubmed-meshheading:21170316-Mice, Nude,
pubmed-meshheading:21170316-NF-kappa B,
pubmed-meshheading:21170316-Prostatic Neoplasms,
pubmed-meshheading:21170316-Protease Inhibitors,
pubmed-meshheading:21170316-Proteasome Endopeptidase Complex,
pubmed-meshheading:21170316-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:21170316-Triterpenes
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Natural proteasome inhibitor celastrol suppresses androgen-independent prostate cancer progression by modulating apoptotic proteins and NF-kappaB.
|
|
pubmed:affiliation |
Department of Radiation Oncology, Division of Radiation and Cancer Biology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
|
