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pubmed:abstractText |
Many inflammatory diseases, as well as infections, are accompanied by elevation in cellular levels of Reactive Oxygen Species (ROS). Here we report that MPYS, a.k.a. STING, which was recently shown to mediate activation of IFN? expression during infection, is a ROS sensor. ROS induce intermolecular disulfide bonds formation in MPYS homodimer and inhibit MPYS IFN? stimulatory activity. Cys-64, -148, -292, -309 and the potential C??xxC?? redox motif in MPYS are indispensable for IFN? stimulation and IRF3 activation. Thus, our results identify a novel mechanism for ROS regulation of IFN? stimulation.
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pubmed:affiliation |
Integrated Department of Immunology, University of Colorado Denver School of Medicine and National Jewish Health, Denver, Colorado, United States of America.
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