Source:http://linkedlifedata.com/resource/pubmed/id/21169554
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2011-9-7
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pubmed:abstractText |
Emphysema is a progressive disease characterized by the destruction of peripheral airspaces and subsequent decline in lung function. However, the relation between structure and function during disease progression is not well understood. The objective of this study was to assess the time course of the structural, mechanical, and remodeling properties of the lung in mice after elastolytic injury. At 2, 7, and 21 days after treatment with porcine pancreatic elastase, respiratory impedance, the constituents of lung extracellular matrix, and histological sections of the lung were evaluated. In the control group, no changes were observed in the structural or functional properties, whereas, in the treatment group, the respiratory compliance and its variability significantly increased by Day 21 (P < 0.001), and the difference in parameters decreased with increasing positive end-expiratory pressure. The heterogeneity of airspace structure gradually increased over time. Conversely, the relative amounts of elastin and type I collagen exhibited a peak (P < 0.01) at Day 2, but returned to baseline levels by Day 21. Structure-function relations manifested themselves in strong correlations between compliance parameters and both mean size and heterogeneity of airspace structure (r(2) > 0.9). Similar relations were also obtained in a network model of the parenchyma in which destruction was based on the notion that mechanical forces contribute to alveolar wall rupture. We conclude that, in a mouse model of emphysema, progressive decline in lung function is sensitive to the development of airspace heterogeneity governed by local, mechanical, force-induced failure of remodeled collagen.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1535-4989
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
517-24
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pubmed:meshHeading |
pubmed-meshheading:21169554-Animals,
pubmed-meshheading:21169554-Collagen,
pubmed-meshheading:21169554-Elastin,
pubmed-meshheading:21169554-Lung,
pubmed-meshheading:21169554-Mice,
pubmed-meshheading:21169554-Mice, Inbred C57BL,
pubmed-meshheading:21169554-Pancreas,
pubmed-meshheading:21169554-Pancreatic Elastase,
pubmed-meshheading:21169554-Positive-Pressure Respiration,
pubmed-meshheading:21169554-Pulmonary Alveoli,
pubmed-meshheading:21169554-Pulmonary Emphysema,
pubmed-meshheading:21169554-Respiration,
pubmed-meshheading:21169554-Stress, Mechanical,
pubmed-meshheading:21169554-Structure-Activity Relationship,
pubmed-meshheading:21169554-Swine,
pubmed-meshheading:21169554-Time Factors
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pubmed:year |
2011
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pubmed:articleTitle |
Structure-function relations in an elastase-induced mouse model of emphysema.
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pubmed:affiliation |
Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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