rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
5
|
pubmed:dateCreated |
2011-4-7
|
pubmed:databankReference |
|
pubmed:abstractText |
Intervention for cystic fibrosis lung disease early in its course has the potential to delay or prevent progressive changes that lead to irreversible airflow obstruction. Denufosol is a novel ion channel regulator designed to correct the ion transport defect and increase the overall mucociliary clearance in cystic fibrosis lung disease by increasing chloride secretion, inhibiting sodium absorption, and increasing ciliary beat frequency in the airway epithelium independently of cystic fibrosis transmembrane conductance regulator genotype.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
1535-4970
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:day |
1
|
pubmed:volume |
183
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
627-34
|
pubmed:meshHeading |
pubmed-meshheading:21169471-Adolescent,
pubmed-meshheading:21169471-Adult,
pubmed-meshheading:21169471-Analysis of Variance,
pubmed-meshheading:21169471-Child,
pubmed-meshheading:21169471-Child, Preschool,
pubmed-meshheading:21169471-Cystic Fibrosis,
pubmed-meshheading:21169471-Deoxycytosine Nucleotides,
pubmed-meshheading:21169471-Double-Blind Method,
pubmed-meshheading:21169471-Female,
pubmed-meshheading:21169471-Humans,
pubmed-meshheading:21169471-Lung,
pubmed-meshheading:21169471-Male,
pubmed-meshheading:21169471-Respiratory Function Tests,
pubmed-meshheading:21169471-Severity of Illness Index,
pubmed-meshheading:21169471-Treatment Outcome,
pubmed-meshheading:21169471-Uridine,
pubmed-meshheading:21169471-Young Adult
|
pubmed:year |
2011
|
pubmed:articleTitle |
Denufosol tetrasodium in patients with cystic fibrosis and normal to mildly impaired lung function.
|
pubmed:affiliation |
University of Colorado Denver, 13123 East 16th Avenue, B395, Aurora, CO 80045. accurso.frank@tchden.org.
|
pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Clinical Trial, Phase III
|