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rdf:type |
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lifeskim:mentions |
umls-concept:C0011847,
umls-concept:C0013227,
umls-concept:C0026336,
umls-concept:C0028754,
umls-concept:C0205314,
umls-concept:C0220908,
umls-concept:C0679622,
umls-concept:C1335280,
umls-concept:C1521991,
umls-concept:C1527178,
umls-concept:C1705938
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pubmed:issue |
2
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pubmed:dateCreated |
2011-1-11
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pubmed:abstractText |
Tyrosine phosphatase Src-homology phosphotyrosyl phosphatase 2 (Shp2) was identified as a potential molecular target for therapeutic treatment of diabetes and obesity. However, there is still no systematic research on the enhancers for the Shp2 enzyme. The present study established a novel powerful model for the high-throughput screening of Shp2 enhancers and successfully identified a new specific Shp2 enhancer, oleanolic acid, from Chinese herbs.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Jan
|
|
pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:BuYanyanY,
pubmed-author:ChenHaifengH,
pubmed-author:ChenQuanchengQ,
pubmed-author:ChengHaifengH,
pubmed-author:FengGenshengG,
pubmed-author:GueJ WJW,
pubmed-author:KongGuipingG,
pubmed-author:LuZhongxianZ,
pubmed-author:MengMinghuiM,
pubmed-author:TianYingpuY,
pubmed-author:XinshengYaoY
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
|
|
pubmed:day |
15
|
|
pubmed:volume |
21
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
874-8
|
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pubmed:dateRevised |
2011-5-17
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pubmed:meshHeading |
pubmed-meshheading:21169016-Animals,
pubmed-meshheading:21169016-Blood Glucose,
pubmed-meshheading:21169016-Diabetes Mellitus,
pubmed-meshheading:21169016-Diabetes Mellitus, Experimental,
pubmed-meshheading:21169016-Drugs, Chinese Herbal,
pubmed-meshheading:21169016-Forsythia,
pubmed-meshheading:21169016-Humans,
pubmed-meshheading:21169016-Hypoglycemic Agents,
pubmed-meshheading:21169016-Mice,
pubmed-meshheading:21169016-Obesity,
pubmed-meshheading:21169016-Oleanolic Acid,
pubmed-meshheading:21169016-Protein Tyrosine Phosphatase, Non-Receptor Type 11
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pubmed:year |
2011
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pubmed:articleTitle |
A novel screening model for the molecular drug for diabetes and obesity based on tyrosine phosphatase Shp2.
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|
pubmed:affiliation |
Xiamen City Key Laboratory of Metabolism Disease and Metabolic Disease Research Center, Institute for Biomedical Research, Lu Jiaxi Hall, Room 630, Xiamen University, Xiamen, Fujian 361005, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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